Recent researches in triazole compounds as medicinal drugs
C -H. Zhou, Y Wang - Current medicinal chemistry, 2012 - benthamdirect.com
Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole
ring are readily able to bind with a variety of enzymes and receptors in biological system via …
ring are readily able to bind with a variety of enzymes and receptors in biological system via …
Comprehensive review on natural pharmacophore tethered 1, 2, 3‐triazoles as active pharmaceuticals
A Rammohan, BC Venkatesh… - Chemical Biology & …, 2023 - Wiley Online Library
Abstract The privileged 1, 2, 3‐triazole scaffold is drawing researcher's attention due to its
widespread applications in diverse fields such as drug discovery (eg, carboxyamidotriazole) …
widespread applications in diverse fields such as drug discovery (eg, carboxyamidotriazole) …
Synthesis, antiproliferative and apoptosis induction potential activities of novel bis (indolyl) hydrazide-hydrazone derivatives
In recent years, indole-indazolyl hydrazide-hydrazone derivatives with strong cell growth
inhibition and apoptosis induction characteristics are being strongly screened for their …
inhibition and apoptosis induction characteristics are being strongly screened for their …
Novel bis (indolyl) hydrazide–hydrazones as potent cytotoxic agents
A series of bis (indolyl) hydrazide–hydrazones 5a–n were synthesized and evaluated for
their cytotoxicity against selected human cancer cell lines. The reaction of indole-3 …
their cytotoxicity against selected human cancer cell lines. The reaction of indole-3 …
Asymmetric synthesis of novel triazole derivatives and their in vitro antiviral activity and mechanism of action
X Cao, W Wang, S Wang, L Bao - European Journal of Medicinal Chemistry, 2017 - Elsevier
In this study, forty-four chiral triazole derivatives have been prepared via asymmetric
synthesis, and which has been successfully characterized by typical spectroscopic …
synthesis, and which has been successfully characterized by typical spectroscopic …
Synthesis, antitumor evaluation, and molecular docking studies of indole–indazolyl hydrazide–hydrazone derivatives
A series of ten novel hydrazide–hydrazones linked indole and indazole moieties were
designed and synthesized. All the synthesized compounds were evaluated for their …
designed and synthesized. All the synthesized compounds were evaluated for their …
Synthesis and in-vitro anticancer activity of 3, 5-bis (indolyl)-1, 2, 4-thiadiazoles
D Kumar, NM Kumar, KH Chang, R Gupta… - Bioorganic & medicinal …, 2011 - Elsevier
A series of 3, 5-bis (indolyl)-1, 2, 4-thiadiazoles were synthesized and evaluated for their
cytotoxicity against selected human cancer cell lines. The reaction of indole-3 …
cytotoxicity against selected human cancer cell lines. The reaction of indole-3 …
Synthesis and identification of α-cyano bis (indolyl) chalcones as novel anticancer agents
Microwave-assisted synthesis of 23 α-cyano bis (indolyl) chalcones (6a–w) and their in vitro
anticancer activity against three human cancer cell lines have been discussed. Among the …
anticancer activity against three human cancer cell lines have been discussed. Among the …
Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents
A new series of diverse isoxazoles and triazoles linked 6-hydroxycoumarin (1) were
synthesized using click chemistry approach. All the derivatives were subjected to 3-(4, 5 …
synthesized using click chemistry approach. All the derivatives were subjected to 3-(4, 5 …
Synthesis and antiproliferative activity of some new thieno [2, 3-d] pyrimidin-4 (3H)-ones containing 1, 2, 4-triazole and 1, 3, 4-thiadiazole moiety
AT Mavrova, D Wesselinova, JA Tsenov… - European Journal of …, 2014 - Elsevier
Abstract Some new thieno [2, 3-d] pyrimidin-4 (3H)-ones containing 1, 2, 4-triazole and 1, 3,
4-thiadiazole moiety were synthesized using thieno [2, 3-d] pyrimidin-3 (4H)-yl) …
4-thiadiazole moiety were synthesized using thieno [2, 3-d] pyrimidin-3 (4H)-yl) …