[HTML][HTML] Molecular mechanisms of atopic dermatitis pathogenesis

J Sroka-Tomaszewska, M Trzeciak - International journal of molecular …, 2021 - mdpi.com
Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic
feature is persistent itching of the skin. The chronic, relapsing course of the disease …

[HTML][HTML] JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review

IH Huang, WH Chung, PC Wu, CB Chen - Frontiers in immunology, 2022 - frontiersin.org
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …

[HTML][HTML] Trial of nemolizumab and topical agents for atopic dermatitis with pruritus

K Kabashima, T Matsumura, H Komazaki… - … England Journal of …, 2020 - Mass Medical Soc
Background Nemolizumab is a subcutaneously administered humanized monoclonal
antibody against interleukin-31 receptor A, which is involved in pruritus and inflammation in …

[HTML][HTML] Targeting the Janus kinase family in autoimmune skin diseases

MD Howell, FI Kuo, PA Smith - Frontiers in immunology, 2019 - frontiersin.org
Autoimmune skin diseases are characterized by significant local and systemic inflammation
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …

[HTML][HTML] Th2 modulation of transient receptor potential channels: an unmet therapeutic intervention for atopic dermatitis

J Meng, Y Li, MJM Fischer, M Steinhoff… - Frontiers in …, 2021 - frontiersin.org
Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …

Keratinocytes: innate immune cells in atopic dermatitis

P Chieosilapatham, C Kiatsurayanon… - Clinical & …, 2021 - academic.oup.com
The skin is a unique immune organ that constitutes a complex network of physical, chemical
and microbiological barriers against external insults. Keratinocytes are the most abundant …

Nomenclature and clinical phenotypes of atopic dermatitis

G Girolomoni, M de Bruin-Weller… - … advances in chronic …, 2021 - journals.sagepub.com
Atopic dermatitis is a heterogeneous disease and resists classification. In this review, we
discuss atopic dermatitis nomenclature and identify morphologic phenotypes, which will …

Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options

T Bieber, AS Paller, K Kabashima… - Journal of the …, 2022 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, heterogenous, inflammatory skin disorder associated
with a high skin‐related health burden, typically starting in childhood and often persisting …

The use of biologics in food allergy

A Fiocchi, BP Vickery, RA Wood - Clinical & Experimental …, 2021 - Wiley Online Library
Background Food allergy continues to pose problems due to its increased frequency and its
increasingly high severity. In this context, alongside the traditional avoidance strategies of …

[HTML][HTML] Bacterial metabolites: a link between gut microbiota and dermatological diseases

A Stec, M Sikora, M Maciejewska… - International Journal of …, 2023 - mdpi.com
Dysbiosis has been identified in many dermatological conditions (eg, psoriasis, atopic
dermatitis, systemic lupus erythematosus). One of the ways by which the microbiota affect …