Hearing loss is the most common congenital sensory impairment. Mutations or deficiencies
of the GJB2 gene are the most common genetic cause of congenital non-syndromic …

Hereditary deafness is one of the most common human birth defects. GJB2 gene mutation is
the most genetic etiology. Gap junction protein 26 (connexin26, Cx26) encoded by the GJB2 …

Abstract Background Nuclear Yes1‐associated transcriptional regulator (YAP1) promotes
tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its …

Better understanding the mechanism of cisplatin-induced ototoxicity is of great significance
for clinical prevention and treatment of cisplatin-related hearing loss. However, the …

Abstract N6-methyladenosine (m6A) has been recognized as a common type of post-
transcriptional epigenetic modification. m6A modification and YTHDF1, one of its reader …

The vertebrate inner ear contains a diversity of unique cell types arranged in a particularly
complex 3D cytoarchitecture. Both of these features are integral to the proper development …

The connexin gene family is the most prevalent gene that contributes to hearing loss.
Connexins 26 and 30, encoded by GJB2 and GJB6, respectively, are the most abundantly …

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes.
The main pathological changes were intestinal mucosal injury. Leucine-rich repeat …

Aminoglycosides are commonly used for the treatment of life-threatening bacterial infections,
however, aminoglycosides may cause irreversible hearing loss with a long-term clinical …

Epigallocatechin-3-gallate (EGCG) is the primary active ingredient in green tea and has
been used for cancer prevention in clinical trials. The anti-tumor effects of EGCG stem from …