Plasmacytoid dendritic cells (pDCs) are a special subtype of dendritic cells with the
morphology of plasma cells. pDCs produce massive amounts of type I interferon (IFN-I) …

Tumor-associated macrophages (TAMs) promote metastasis and inhibit T cells, but
macrophages can be polarized to kill cancer cells. Macrophage polarization could thus be a …

Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing
nanotechnology to augment traditional vaccine efficacy. This review comprehensively …

Laminaria japonica is a brown alga and is composed primarily of polysaccharides. Fucoidan
and laminarin are the major polysaccharides of L. japonica and exhibit biological activities …

Macrophages represent the most prevalent immune cells in the tumor micro-environment,
making them an appealing target for tumor immunotherapy. One of our previous studies …

Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune
stimulatory effects that elicit anticancer immunity, mucosal adjuvant effects via intranasal …

Macrophages comprise a significant portion of the immune cell compartment within tumors
and are known contributors to tumor pathology; however, cancer immunotherapies targeting …

Fucoidan is a sulfated polysaccharide, derived from various marine brown seaweeds, that
has immunomodulatory effects. In this study, we analyzed the effects of five different …

Background Advanced cancer therapy is targeted at primary tumors and also recurrent or
metastatic cancers. Combinational cancer treatment has recently shown high efficiency …

Background Radiation therapy (RT) has been demonstrated to generate an in situ
vaccination (ISV) effect in murine models and in patients with cancer; however, this has not …