At any point 1–5 days following ascent to altitudes≥ 2500 m, individuals are at risk of
developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome …

Quantitative measurements of brain perfusion are influenced by perfusion-modifiers.
Standardization of measurement conditions and correction for important modifiers is …

Red blood cells (RBCs) are key players in systemic oxygen transport. RBCs respond to in
vitro hypoxia through the so-called oxygen-dependent metabolic regulation, which involves …

An understanding of human responses to hypoxia is important for the health of millions of
people worldwide who visit, live, or work in the hypoxic environment encountered at high …

Ascent to high-altitude elicits compensatory physiological adaptations in order to improve
oxygenation throughout the body. The brain is particularly vulnerable to the hypoxemia of …

Cerebral blood flow (CBF) regulation can be impaired in acute ischemic stroke but the
combined effects of dynamic cerebral autoregulation (CA), CO2 cerebrovascular reactivity …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

Purpose: To outline how hypoxia profoundly affects neuronal functionality and thus
compromises exercise performance. Methods: Investigations were reviewed and evaluated …

The effects of partial acclimatization to high altitude (HA; 5,050 m) on cerebral metabolism
and cerebrovascular function have not been characterized. We hypothesized (1) increased …

Normative values of physiological parameters hold significance in modern day clinical
decision-making. Lack of such normative values has been a major hurdle in the translation …