Ethnopharmacological relevance Evodia rutaecarpa, a well-known herb medicine in China,
is extensively applied in traditional Chinese medicine (TCM). The plant has the effects of …

Melatonin is a pleiotropic, indole secreted, and synthesized by the human pineal gland.
Melatonin has biological effects including anti-apoptosis, protecting mitochondria, anti …

Ethnopharmacological relevance The fruit of Tetradium ruticarpum (FTR) known as Tetradii
fructus or Evodiae fructus (Wu-Zhu-Yu in Chinese) is a versatile herbal medicine which has …

It is a well-known phenomenon that natural products can serve as powerful drug leads to
generate new molecular entities with novel therapeutic utility. Evodiamine (Evo), a major …

Organocatalytic asymmetric [3+ 3] annulations of isatin-derived MBH carbonates and indolin-
2-imines were efficiently achieved. This appears to be the first enantioselective approach for …

Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone
scaffold was designed by scaffold hopping. Structure–activity relationship studies led to the …

Fluorescent probes are attractive tools for biology, drug discovery, disease diagnosis, and
environmental analysis. In bioimaging, these easy-to-operate and inexpensive probes can …

Here, evodiamine (EVO) and the photosensitizer indocyanine green (ICG) were integrated
into a liposomal nanoplatform for noninvasive diagnostic imaging and combinatorial therapy …

A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds
with therapeutic advantages over single target inhibitors and drug combinations. Inspired by …

Evodiamine (Evo) is a quinazolinocarboline alkaloid found in Evodia rutaecarpa and
exhibits moderate antiproliferative activity. Herein, we report using a scaffold-hopping …