Applications of radiocomplexes with thiosemicarbazones and bis (thiosemicarbazones) in diagnostic and therapeutic nuclear medicine

GL Parrilha, RG dos Santos, H Beraldo - Coordination Chemistry Reviews, 2022 - Elsevier
Metallic radionuclides possess a variety of half-lives, emission types, energies, and
branching ratios, making it possible to apply them as diagnostic and/or therapeutic agents …

Modulation of the lipophilicity and molecular size of thiosemicarbazone inhibitors to regulate tyrosinase activity

S Cao, D Wang, R Cheng, W Shi, Q Zhang… - … Acta Part A: Molecular …, 2022 - Elsevier
A group of 5-methylsalicylaldehyde thiosemicarbazone derivatives (HMTs) bearing different
lipophilic and steric substituents attached at the 3-position of cresol ring were synthesized …

Comparative evaluation of the structure and antitumor mechanism of mononuclear and trinucleated thiosemicarbazone Cu (II) complexes

Y Zheng, K Wei, Y Gao, Z Zhou, X Zheng, J Li… - Journal of Inorganic …, 2023 - Elsevier
The ratio of ligand to Cu (II) ions has an essential effect on the geometrical configuration and
anti-tumour activity of metal-based complexes. In this work, we synthesised two Cu (II) …

Anticancer Activity and Mode of Action of Copper (II)‐Bis (thiosemicarbazonato) Complexes with Pendant Nitrogen Heterocycles

E Palma, P Raposinho, MPC Campello… - European Journal of …, 2021 - Wiley Online Library
Exploring the potential of bis (thiosemicarbazones)(BTSC), a new family of BTSC ligands
derived from GTSM (glyoxal‐bis (N4‐methylthiosemicarbazonato) and respective CuIIBTSC …

Exploring DNA binding ability of two novel α-N-heterocyclic thiosemicarbazone palladium (II) complexes

L Fuentes, AG Quiroga, JA Organero… - Journal of Inorganic …, 2020 - Elsevier
One mononuclear and another dinuclear Pd (II) complexes bearing a α-N-heterocyclic
thiosemicarbazone ligand have been synthesized, fully characterized and studied as …

Synthesis, structures, and DFT analysis of gold complexes containing a thiosemicarbazone ligand

AH Mageed, K Al-Ameed - New Journal of Chemistry, 2021 - pubs.rsc.org
In this study, we report the synthesis of a series of new gold compounds in different solvation
media. First, gold (I) thiosemicarbazone (TSC)[Au–(TSC) 2] Cl was synthesized by reacting …

Identification of 3-bromo-1-ethyl-1H-indole as a potent anticancer agent with promising inhibitory effects on GST isozymes

C Yılmaz, S Arslan, D Mutlu, M Konus… - Anti-Cancer Agents …, 2021 - ingentaconnect.com
Background: Indole-based heterocyclic compounds play important roles in pharmaceutical
chemistry due to their unexpected biological and pharmacological properties. Objective …

5-Substituted isatin thiosemicarbazones as inhibitors of tyrosinase: Insights of substituent effects

R Cheng, W Shi, Q Yuan, R Tang, Y Wang… - … Acta Part A: Molecular …, 2021 - Elsevier
Seven isatin-thiosemicarbazone analogues bearing different substituents (R) attached at C-
5 of the indoline ring, TSC-ISA-R (R=-H,-CH 3,-OCH 3,-OCF 3,-F,-Cl and-NO 2), were …

Unravelling the antitumoral potential of novel bis (thiosemicarbazonato) Zn (II) complexes: structural and cellular studies

E Palma, HM Botelho, GR Morais, I Rodrigues… - JBIC Journal of …, 2019 - Springer
The development of pharmacologically active compounds based on bis
(thiosemicarbazones)(BTSC) and on their coordination to metal centers constitutes a …

[PDF][PDF] PHARMACEUTICAL SCIENCES

TRR Timóteo, VAW Sales, A Luiz, LA Rolim, PJR Neto - pdfs.semanticscholar.org
Background: Classified as a Group IIIA metal, gallium, as well as its compounds, has been
presenting several therapeutic activities in the last decades. Gallium compounds garnered …