The purpose of this review is to summarize current knowledge about the role of the
Hedgehog signaling pathway in liver homeostasis and disease. Hedgehog is a …

Background & Aims In the developing liver, bipotent epithelial progenitor cells undergo
lineage segregation to form hepatocytes, which constitute the bulk of the liver parenchyma …

Next-generation sequencing (NGS) technologies have revolutionized diagnostic
approaches, while discovery of new intracellular signaling pathways show promise in …

Background Biliary atresia (BA) is a rare condition of unknown origin in newborns with
jaundice. In BA bile ducts are non-functional, causing neonatal cholestasis and following …

Background Biliary atresia (BA) is an intractable disease of unknown cause that develops in
the neonatal period. It causes jaundice and liver damage due to the destruction of …

Background Biliary atresia (BA) is a severe neonatal progressive cholangiopathy of
unknown etiology. A timely Kasai portoenterostomy (KPE) improves survival of the native …

While apical-basal polarity refers to the distribution of cellular components between the
apical and basal poles of a cell, planar cell polarity (PCP) refers to the coordinated …

Biliary atresia (BA) is a neonatal fibro-obliterative disease of the extrahepatic bile ducts.
Already in the first days to weeks after birth BA manifests in affected children with (sub) total …

Objective: This study aims to investigate the correlation between matrix metalloproteinase-
13 (MMP-13) expression in the liver of patients with biliary atresia and various factors …

Impaired formation of the biliary network can lead to congenital cholestatic liver diseases;
however, the genes responsible for proper biliary system formation and maintenance have …