Small RNAs, large networks: posttranscriptional regulons in gram-negative bacteria

K Papenfort, S Melamed - Annual Review of Microbiology, 2023 - annualreviews.org
Small regulatory RNA (sRNAs) are key mediators of posttranscriptional gene control in
bacteria. Assisted by RNA-binding proteins, a single sRNA often modulates the expression …

[HTML][HTML] Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Heme synthesis and acquisition in bacterial pathogens

JE Choby, EP Skaar - Journal of molecular biology, 2016 - Elsevier
Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …

Interplay between iron homeostasis and virulence: Fur and RyhB as major regulators of bacterial pathogenicity

G Porcheron, CM Dozois - Veterinary microbiology, 2015 - Elsevier
In bacteria–host interactions, competition for iron is critical for the outcome of the infection.
As a result of its redox properties, this metal is essential for the growth and proliferation of …

[HTML][HTML] Extracellular DNA release, quorum sensing, and PrrF1/F2 small RNAs are key players in Pseudomonas aeruginosa tobramycin-enhanced biofilm formation

A Tahrioui, R Duchesne, E Bouffartigues… - npj Biofilms and …, 2019 - nature.com
Biofilms are structured microbial communities that are the leading cause of numerous
chronic infections which are difficult to eradicate. Within the lungs of individuals with cystic …

Bacterial iron homeostasis regulation by sRNAs

S Chareyre, P Mandin - Microbiology spectrum, 2018 - Am Soc Microbiol
While iron is essential to sustain growth, its excess can be detrimental to the cell by
generating highly toxic reactive oxygen species. Regulation of iron homeostasis thus plays a …

Mechanisms of iron homeostasis in Pseudomonas aeruginosa and emerging therapeutics directed to disrupt this vital process

A Sánchez‐Jiménez, FJ Marcos‐Torres… - Microbial …, 2023 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic pathogen able to infect any human tissue.
One of the reasons for its high adaptability and colonization of host tissues is its capacity of …

Ferric chloride induces ferroptosis in Pseudomonas aeruginosa and heals wound infection in a mouse model

M Huang, Z Wang, L Yao, L Zhang, X Gou, H Mo… - International journal of …, 2023 - Elsevier
Background Pseudomonas aeruginosa is one of the most common pathogens that lead to
fatal human infection. This Gram-negative pathogen has evolved complex drug resistance …

[HTML][HTML] Phenotypic and transcriptional study of the antimicrobial activity of silver and zinc oxide nanoparticles on a wastewater biofilm-forming Pseudomonas …

M De Celis, I Belda, D Marquina, A Santos - Science of The Total …, 2022 - Elsevier
The extensive use of nanoparticles (NPs) in industrial processes makes their potential
release into the environment an issue of concern. Ag and ZnO NPs are among the most …

[HTML][HTML] RNA-dependent regulation of virulence in pathogenic bacteria

S Chakravarty, E Massé - Frontiers in cellular and infection …, 2019 - frontiersin.org
During infection, bacterial pathogens successfully sense, respond and adapt to a myriad of
harsh environments presented by the mammalian host. This exquisite level of adaptation …