The transition to compulsion in addiction
Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …
However, compulsion is observed in only a small proportion of individuals who repeatedly …
[HTML][HTML] Drug-induced conditioned place preference and its practical use in substance use disorder research
G McKendrick, NM Graziane - Frontiers in behavioral neuroscience, 2020 - frontiersin.org
The conditioned place preference (CPP) paradigm is a well-established model utilized to
study the role of context associations in reward-related behaviors, including both natural …
study the role of context associations in reward-related behaviors, including both natural …
[HTML][HTML] Neurocircuitry of addiction
GF Koob, ND Volkow - Neuropsychopharmacology, 2010 - nature.com
Drug addiction is a chronically relapsing disorder that has been characterized by (1)
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …
[HTML][HTML] Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats
C Aranäs, CE Edvardsson, OT Shevchouk, Q Zhang… - …, 2023 - thelancet.com
Background Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …
The mammalian circadian timing system: organization and coordination of central and peripheral clocks
C Dibner, U Schibler, U Albrecht - Annual review of physiology, 2010 - annualreviews.org
Most physiology and behavior of mammalian organisms follow daily oscillations. These
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity …
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity …
Animal models of addiction
R Spanagel - Dialogues in clinical neuroscience, 2017 - Taylor & Francis
In recent years, animal models in psychiatric research have been criticized for their limited
translational value to the clinical situation. Failures in clinical trials have thus often been …
translational value to the clinical situation. Failures in clinical trials have thus often been …
[HTML][HTML] Reward processing by the opioid system in the brain
J Le Merrer, JAJ Becker, K Befort… - Physiological …, 2009 - journals.physiology.org
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by
endogenous opioid peptides processed from three protein precursors, proopiomelanocortin …
endogenous opioid peptides processed from three protein precursors, proopiomelanocortin …
[HTML][HTML] Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: potential therapeutic impacts
AP Daiwile, S Jayanthi, JL Cadet - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Methamphetamine (METH) use, and misuse are associated with severe socioeconomic
consequences. METH users develop tolerance, lose control over drug taking behaviors, and …
consequences. METH users develop tolerance, lose control over drug taking behaviors, and …
The role of serotonin in drug use and addiction
CP Müller, JR Homberg - Behavioural brain research, 2015 - Elsevier
The use of psychoactive drugs is a wide spread behaviour in human societies. The
systematic use of a drug requires the establishment of different drug use-associated …
systematic use of a drug requires the establishment of different drug use-associated …
From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction
Kratom (or Ketum) is a psychoactive plant preparation used in Southeast Asia. It is derived
from the plant Mitragyna speciosa Korth. Kratom as well as its main alkaloid, mitragynine …
from the plant Mitragyna speciosa Korth. Kratom as well as its main alkaloid, mitragynine …