Major progress has been made in defining the basis of the mitochondrial permeability
transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …

Autophagy is a catabolic process aimed at recycling cellular components and damaged
organelles in response to diverse conditions of stress, such as nutrient deprivation, viral …

Macroautophagy/autophagy is an evolutionarily well-conserved recycling process in
response to stress conditions, including a burst of reactive oxygen species (ROS) …

Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity.
How GCBCs meet the energetic challenge of rapid proliferation is poorly understood …

The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

The heart is the most metabolically flexible organ with respect to the use of substrates
available in different states of energy metabolism. Cardiac mitochondria sense substrate …

Accumulating evidence reveals that metabolic and cell survival pathways are closely
related, sharing common signaling molecules. Hexokinase catalyzes the phosphorylation of …

Mitochondrial reactive oxygen species (ROS) production and detoxification are tightly
balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce …