The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Bacilli as sources of agrobiotechnology: recent advances and future directions

ZT Dame, M Rahman, T Islam - Green Chemistry Letters and …, 2021 - Taylor & Francis
The group bacilli represent the Gram-positive ubiquitous spore-forming bacteria. Their
diversity, versatility and the ability of producing diverse secondary metabolites including …

Purification, physicochemical properties, and statistical optimization of fibrinolytic enzymes especially from fermented foods: a comprehensive review

AMM Ali, SCB Bavisetty - International Journal of Biological …, 2020 - Elsevier
Fibrinolytic enzymes are proteases responsible for cleavage of fibrin mesh in thrombus clots,
which are the primary causative agents in cardiovascular diseases. Developing safe …

Attenuation of neurobehavioral and neurochemical abnormalities in animal model of cognitive deficits of Alzheimer's disease by fermented soybean nanonutraceutical

PC Bhatt, S Pathak, V Kumar, BP Panda - Inflammopharmacology, 2018 - Springer
The present study was performed to evaluate the efficacy of nanonutraceuticals (NN) for
attenuation of neurobehavioral and neurochemical abnormalities in Alzheimer's disease …

Development of surface-engineered PLGA nanoparticulate-delivery system of Tet1-conjugated nattokinase enzyme for inhibition of Aβ40 plaques in Alzheimer's …

PC Bhatt, A Verma, FA Al-Abbasi, F Anwar… - International journal …, 2017 - Taylor & Francis
According to the World Health Organization, globally there are around 18 million patients
suffering from Alzheimer's disease (AD), and this number is expected to double by 2025 …

Research progress on the utilisation of embedding technology and suitable delivery systems for improving the bioavailability of nattokinase: a review

X Zhou, L Liu, X Zeng - Food Structure, 2021 - Elsevier
Nattokinase is a thrombolytic drug that is more advantageous than urokinase, streptokinase,
and tissue plasminogen activator because of its low price, high efficiency, and nontoxic side …

[HTML][HTML] Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation

M Fang, B Yuan, M Wang, J Liu, Z Wang - Fermentation, 2023 - mdpi.com
Nattokinase, a serine protease that originates from the traditional food natto, has garnered
widespread attention due to its pharmacological functions and therapeutic potential. This …

Automated microscopic measurement of fibrinaloid microclots and their degradation by nattokinase, the main natto protease

JM Grixti, CW Theron, JE Salcedo-Sora, E Pretorius… - bioRxiv, 2024 - biorxiv.org
Nattokinase, from the Japanese fermented food natto, is a protease with fibrinolytic activity
that can thus degrade conventional blood clots. In some cases, however, including in Long …

[HTML][HTML] Design of expert guided investigation of native L-asparaginase encapsulated long-acting cross-linker-free poly (lactic-co-glycolic) acid nanoformulation in an …

M Singh, N Hassan, D Verma, P Thakur… - Saudi Pharmaceutical …, 2020 - Elsevier
Present study explores native L-asparaginase encapsulated long-acting cross-linker-free
PLGA-nanoformulation in an Ehrlich ascites tumor model. L-asparaginase-PLGA …

Divalent toxoids loaded stable chitosan–glucomannan nanoassemblies for efficient systemic, mucosal and cellular immunostimulatory response following oral …

H Harde, K Siddhapura, AK Agrawal, S Jain - International Journal of …, 2015 - Elsevier
The present study reports dual tetanus and diphtheria toxoids loaded stable chitosan–
glucomannan nanoassemblies (sCh–GM-NAs) formulated using tandem ionic gelation …