Since the identification of B‐cell translocation gene 1 (BTG1) and BTG2 as antiproliferation
genes more than two decades ago, their protein products have been implicated in a variety …

Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the
Philadelphia chromosome as the sole genetic abnormality into blast crisis, which is often …

Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to
understand the mechanisms that lead to treatment resistance. To this end, we analyzed …

Although the importance of the ARF tumor suppressor in p53 regulation is well established,
numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2 …

The Arf tumor suppressor inhibits cell cycle progression through both p53-dependent and
p53-independent mechanisms, including interference with rRNA processing. Using tandem …

The nucleolus is a sub-nuclear body known primarily for its role in ribosome biogenesis.
Increased number and/or size of nucleoli have historically been used by pathologists as a …

The p19 Arf tumor suppressor, a nucleolar protein, binds to Mdm2 to induce p53-dependent
cell cycle arrest. Arf also prevents the proliferation of cells lacking Mdm2 and p53, albeit less …

Unknown mechanisms govern degradation of the p19Arf tumor suppressor, an activator of
p53 and inhibitor of ribosomal RNA processing. Kinetic metabolic labeling of cells with [3H] …

One mechanism by which a cell affords protection from the transforming effects of
oncogenes is via the action of the tumor suppressor, ARF, which activates p53 by …

The tumor suppressor p53 is tightly controlled at low levels in cells by constant ubiquitination
and proteasomal degradation. In response to stresses, ubiquitination of p53 is inhibited …