The regulatory pathways required to maintain eukaryotic lipid homeostasis are largely
unknown. We developed a systematic approach to uncover new players in the regulation of …

Huntington's disease is a devastating neurodegenerative disorder that onsets in late
adulthood as progressive and terminal cognitive, psychiatric and motor deficits. The disease …

Huntington's disease (HD) is an autosomal dominant neurodegenerative illness caused by a
mutation in the huntingtin gene (HTT) and subsequent protein (mhtt), to which the brain …

The maintenance of the characteristic lipid compositions and physicochemical properties of
biological membranes is essential for their proper function. Mechanisms allowing to sense …

Macroautophagy/autophagy is an evolutionarily conserved biological process among
eukaryotes that degrades unwanted materials such as protein aggregates, damaged …

Introduction Metabolic changes have been frequently associated with Huntington's disease
(HD). At the same time peripheral blood represents a minimally invasive sampling avenue …

Coupling cell wall expansion with cell growth is a universal challenge faced by walled
organisms. Mutations in Schizosaccharomyces pombe css1, which encodes a PM inositol …

Animals and fungi produce cholesterol and ergosterol, respectively, while plants produce
the phytosterols stigmasterol, campesterol, and β‐sitosterol in various combinations. The …

Candida albicans and its related species can cause opportunistic infections such as
“candidiasis” in immunocompromised individuals with a high morbidity and mortality rate …

Sphingolipids (SL) are a class of chemically diverse lipids that have important structural and
physiological functions in eukaryotic cells. SL entail a long chain base (LCB) as the common …