Though type 1 diabetes (T1D) is considered a T cell-mediated autoimmune disorder, recent
evidence indicates that B cells play a critical role in disease. This conclusion is based in part …

A classic understanding of the interplay between B and T cell components of the immune
system that drive autoimmunity, where B cells provide an effector function, is represented by …

For autoimmune conditions like type 1 diabetes to progress, self-reactive CD8+ T cells
would need to interact with peptide–antigen cross-presented on the surface of antigen …

OBJECTIVE—B-cells are important for disease pathogenesis in the nonobese diabetic
(NOD) mouse model of type 1 diabetes. Recent studies demonstrate that marginal-zone B …

B lymphocytes are required for the pathogenesis of autoimmune diabetes in NOD mice.
Previous studies established that a lymphopenic transitional (TR) B cell compartment …

Continued antibody gene rearrangement, termed receptor editing, is an important
mechanism of central B cell tolerance that may be defective in some autoimmune …

Abstract Notch2 and Delta-like 1 (Dll1) have been implicated in the development of marginal
zone B (MZB) cells. In the present study, we characterized the expression and function of …

Early breaches in B cell tolerance are central to type 1 diabetes progression in mouse and
man. Conventional BCR transgenic mouse models (VH125. Tg NOD) reveal the power of B …

B cells play a pathogenic role as antigen-presenting cells and autoantibody secretors in the
lead up to T cell-mediated autoimmune destruction of insulin-producing β cells in type 1 …

Regulation of BCR signalling strength is crucial for B‐cell development and function. Bright
is a B‐cell‐restricted factor that complexes with Bruton's tyrosine kinase (Btk) and its …