Biological hypotheses, risk factors, and biomarkers of schizophrenia

Z Fišar - Progress in Neuro-Psychopharmacology and …, 2023 - Elsevier
Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

Intracellular molecular targets and signaling pathways involved in antioxidative and neuroprotective effects of cannabinoids in neurodegenerative conditions

A Tadijan, I Vlašić, J Vlainić, D Đikić, N Oršolić… - Antioxidants, 2022 - mdpi.com
In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic
cannabinoids have received growing interest as treatment options in neurodegenerative …

Endocannabinoid system: chemical characteristics and biological activity

B Rezende, AKN Alencar, GF de Bem… - Pharmaceuticals, 2023 - mdpi.com
The endocannabinoid system (eCB) has been studied to identify the molecular structures
present in Cannabis sativa. eCB consists of cannabinoid receptors, endogenous ligands …

[HTML][HTML] Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior

EM Di Bonaventura, L Botticelli, F Del Bello… - Pharmacological …, 2021 - Elsevier
The peripheral peptide hormone ghrelin is a powerful stimulator of food intake, which leads
to body weight gain and adiposity in both rodents and humans. The hormone, thus …

Modulatory role of the endocannabinoidome in the pathophysiology of the gastrointestinal tract

J Lian, I Casari, M Falasca - Pharmacological Research, 2022 - Elsevier
Abstract Originating from Eastern Asia, the plant Cannabis sativa has been used for
centuries as a medicinal treatment. The unwanted psychotropic effects of one of its major …

Prenatal exposure to Δ9-tetrahydrocannabinol affects hippocampus-related cognitive functions in the adolescent rat offspring: focus on specific markers of …

V Castelli, G Lavanco, S Feo, C D'Amico, V Micale… - Pharmaceutics, 2023 - mdpi.com
Previous evidence suggests that prenatal exposure to THC (pTHC) derails the
neurodevelopmental trajectories towards a vulnerable phenotype for impaired emotional …

Sex-Related and Brain Regional Differences of URB597 Effects on Modulation of MAPK/PI3K Signaling in Chronically Stressed Rats

M Jankovic, N Spasojevic, H Ferizovic… - Molecular …, 2024 - Springer
Gender differences exist in depression incidence and antidepressant efficacy. In addition to
the neurotransmission theory of depression, inflammation and disrupted signaling pathways …

The emerging role of the endocannabinoidome-gut microbiome axis in eating disorders

HD Mir, G Giorgini, V Di Marzo - Psychoneuroendocrinology, 2023 - Elsevier
Among the sources of chemical signals regulating food intake, energy metabolism and body
weight, few have attracted recently as much attention as the expanded endocannabinoid …

Cannabinoid cb2 receptors in neurodegenerative proteinopathies: New insights and therapeutic potential

B Vuic, T Milos, L Tudor, M Konjevod… - Biomedicines, 2022 - mdpi.com
Some of the most prevalent neurodegenerative disorders, including Alzheimer's and
Parkinson's disease, are proteinopathies characterized by the accumulation of specific …

rTMS ameliorates depressive‐like behaviors and regulates the gut microbiome and medium‐and long‐chain fatty acids in mice exposed to chronic unpredictable mild …

CH Zhou, YH Chen, SS Xue, QQ Shi… - CNS Neuroscience …, 2023 - Wiley Online Library
Introduction Repetitive transcranial magnetic stimulation (rTMS) is a clinically useful therapy
for depression. However, the effects of rTMS on the metabolism of fatty acids (FAs) and the …