Potential therapeutic and pharmacological effects of Wogonin: an updated review

DL Huynh, TH Ngau, NH Nguyen, GB Tran… - Molecular Biology …, 2020 - Springer
Flavonoids are members of polyphenolic compounds, which are naturally presented in fruits,
vegetables, and some medicinal plants. Traditionally, the root of Scutellaria baicalensis is …

New targets and strategies for rheumatoid arthritis: from Signal transduction to epigenetic aspect

M Zhu, Q Ding, Z Lin, R Fu, F Zhang, Z Li, M Zhang… - Biomolecules, 2023 - mdpi.com
Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to joint damage
and even permanent disability, seriously affecting patients' quality of life. At present, the …

Elucidation of the anti-inflammatory mechanism of Er Miao San by integrative approach of network pharmacology and experimental verification

B Guo, CP Zhao, C Zhang, Y Xiao, G Yan, L Liu… - Pharmacological …, 2022 - Elsevier
Traditional Chinese medicine (TCM) has been long time used in China and gains ever-
increasing worldwide acceptance. Er Miao San (EMS), a TCM formula, has been extensively …

Wogonin alleviates liver injury in sepsis through Nrf2‐mediated NF‐κB signalling suppression

JM Dai, WN Guo, YZ Tan, KW Niu… - Journal of cellular …, 2021 - Wiley Online Library
Sepsis is a life‐threatening organ dysfunction syndrome, and liver is a susceptible target
organ in sepsis, because the activation of inflammatory pathways contributes to septic liver …

Inhibition of NF-κB signaling and HSP70/HSP90 proteins by newly synthesized hydrazide derivatives in arthritis model

AU Khan, A Khan, A Khan, B Shal, A Aziz… - Naunyn-Schmiedeberg's …, 2021 - Springer
In the current study, the N-benzylidene-4-((2-hydroxynaphthalene-1-yl) diazenyl) hydrazides
(NCHDH and NTHDH) were evaluated against the Carrageenan-and CFA-induced models …

Network Pharmacology and Molecular Docking‐Based Prediction of the Mechanism of Qianghuo Shengshi Decoction against Rheumatoid Arthritis

Z Zeng, J Hu, J Jiang, G Xiao, R Yang… - BioMed research …, 2021 - Wiley Online Library
Qianghuo Shengshi decoction (QHSSD) is a classical Chinese medicine formula, which is
used in clinical practice for the treatment of rheumatoid arthritis (RA) in China. However, the …

Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases

J Wang, S Chen, J Zhang, J Wu - Frontiers in pharmacology, 2022 - frontiersin.org
Autoimmune diseases a group of disorders elicited by unexpected outcome of lymphocytes
self-tolerance failure, and the common members of which include multiple sclerosis …

Anti-Arthritic and Immunomodulatory Potential of Methanolic, n-Hexane, and Ethyl Acetate Fractions of Bark of Acacia modesta on Complete Freund's Adjuvant …

K Mashaal, A Shabbir, MA Khan, H Hameed… - Pharmaceutics, 2023 - mdpi.com
Rheumatoid arthritis is an autoimmune disorder and topic of interest for researchers due to
its increasing frequency and limited treatment. Acacia modesta Wall is known to treat …

Wogonin inhibits the migration and invasion of fibroblast-like synoviocytes by targeting PI3K/AKT/NF-κB pathway in rheumatoid arthritis

H Yang, C Liu, X Lin, X Li, S Zeng, Z Gong, Q Xu… - Archives of Biochemistry …, 2024 - Elsevier
Background Rheumatoid arthritis (RA) is currently an autoimmune inflammatory disease
with an unclear pathogenesis. Fibroblast-like synoviocytes (FLSs) have tumor-like …

An optimized machine learning method for predicting wogonin therapy for the treatment of pulmonary hypertension

Y Li, Y Fu, Y Liu, D Zhao, L Liu, S Bourouis… - Computers in Biology …, 2023 - Elsevier
Human health is at risk from pulmonary hypertension (PH), characterized by decreased
pulmonary vascular resistance and constriction of the pulmonary vessels, resulting in right …