Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein
degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits …

FAK is a nonreceptor intracellular tyrosine kinase which plays an important biological
function. Many studies have found that FAK is overexpressed in many human cancer cell …

Focal adhesion kinase (FAK, also known as PTK2) is a tyrosine kinase that regulates
integrin and growth factor signaling pathways and is involved in the migration, proliferation …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase over-expressed in different
solid cancers. In recent years, FAK has been recognized as a new target for the …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and distributes important
regulatory functions in skeletal system. Mesenchymal stem cell (MSC) possesses significant …

Proteolysis targeting chimeras (PROTACs), which hijack proteins of interest (POIs) and
recruit E3 ligases for target degradation via the ubiquitin-proteasome pathway, are a novel …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase over-expressed and
activated in both adult and pediatric cancers, where it plays important roles in the regulation …

Kinase dysregulation is greatly associated with cell proliferation, migration and survival,
indicating the importance of kinases as therapeutic targets for anticancer drug development …

Background: Accumulating studies manifest that BTB and CNC homology 1 (BACH1)
facilitates multiple malignancies progression and metastasis, and targeting the BACH1 …

Epigenetic regulation and Focal adhesion kinase (FAK) are considered to be two important
targets for the development of antitumor drugs. Studies have shown that the combination of …