Regulation of KSHV latency and lytic reactivation

G Broussard, B Damania - Viruses, 2020 - mdpi.com
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three malignancies—
Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's …

Kaposi sarcoma updates

SA Etemad, AK Dewan - Dermatologic clinics, 2019 - derm.theclinics.com
KS, with its distinct clinical variants, presents a unique challenge for clinical care. The advent
of ART in the mid-1990s was a major advance in the treatment of AIDS KS, and the …

N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated …

CR Hesser, J Karijolich, D Dominissini, C He… - PLoS …, 2018 - journals.plos.org
Methylation at the N 6 position of adenosine (m6A) is a highly prevalent and reversible
modification within eukaryotic mRNAs that has been linked to many stages of RNA …

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4

A Kumar, Y Lyu, Y Yanagihashi, C Chantarasrivong… - Cell reports, 2022 - cell.com
Kaposi sarcoma-associated herpesvirus (KSHV) establishes a latent infection in the cell
nucleus, but where KSHV episomal genomes are tethered and the mechanisms underlying …

SARS‐CoV‐2 infection and lytic reactivation of herpesviruses: A potential threat in the postpandemic era?

J Chen, J Song, L Dai, SR Post… - Journal of medical …, 2022 - Wiley Online Library
The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which
is the causative pathogen for the coronavirus disease 2019 (COVID‐19) pandemic, has …

Herpesviral latency—common themes

M Weidner-Glunde, E Kruminis-Kaszkiel… - Pathogens, 2020 - mdpi.com
Latency establishment is the hallmark feature of herpesviruses, a group of viruses, of which
nine are known to infect humans. They have co-evolved alongside their hosts, and mastered …

SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus

J Chen, L Dai, L Barrett, J James… - Communications …, 2021 - nature.com
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of Coronavirus
Disease-2019 (COVID-19), a respiratory disease, has infected almost one hundred million …

KSHV: immune modulation and immunotherapy

G Broussard, B Damania - Frontiers in immunology, 2020 - frontiersin.org
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is associated with KS, primary
effusion lymphoma (PEL), and multicentric Castleman disease (MCD). To ensure its own …

Shiftless restricts viral gene expression and influences RNA granule formation during Kaposi's sarcoma-associated herpesvirus lytic replication

W Rodriguez, T Mehrmann, D Hatfield… - Journal of …, 2022 - Am Soc Microbiol
Herpesviral infection reflects thousands of years of coevolution and the constant struggle
between virus and host for control of cellular gene expression. During Kaposi's sarcoma …

Antiviral activity and mechanisms of seaweeds bioactive compounds on enveloped viruses—A review

S Lomartire, AMM Gonçalves - Marine Drugs, 2022 - mdpi.com
In the last decades, the interest in seaweed has significantly increased. Bioactive
compounds from seaweed's currently receive major attention from pharmaceutical …