The innate immune landscape of the central nervous system (CNS), including the brain and
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …

Inflammaging is a term used to describe the tight relationship between low-grade chronic
inflammation and aging that occurs during physiological aging in the absence of evident …

The major neuropathological hallmarks of Alzheimer's disease (AD) are amyloid β (Aβ)
plaques and neurofibrillary tangles (NFT), accompanied by neuroinflammation and neuronal …

As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …

Dietary interventions can ameliorate age-related neurological decline. Decades of research
of in vitro studies, animal models, and clinical trials support their ability and efficacy to …

Hepatic encephalopathy (HE) is a common complication of chronic liver disease,
characterized by an altered mental state and hyperammonemia. Insight into the brain …

Ischemic stroke is a leading cause of disability and mortality. Despite extensive efforts in
stroke research, the only pharmacological treatment currently available is arterial …

The older population is increasing worldwide, and life expectancy is continuously rising,
predominantly thanks to medical and technological progress. Healthspan refers to the …

Microglial homeostasis has emerged as a critical mediator of health and disease in the
central nervous system. In their neuroprotective role as the predominant immune cells of the …

Recent studies have highlighted the deleterious contributions of B cells to post-stroke
recovery and cognitive decline. Different B cell subsets have been proposed on the basis of …