The neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease (PD)
both have a myriad of risk factors including genetics, environmental exposures, and lifestyle …

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by
several pathological features, including selective neuronal loss, aggregation of specific …

The process of cellular senescence is rapidly emerging as a modulator of organismal aging
and disease. Targeting the development and removal of senescent cells is considered a …

The greatest risk factor for neurodegeneration is the aging of the multiple cell types of
human CNS, among which microglia are important because they are the “sentinels” of …

The blood–brain barrier (BBB) is a critical physiochemical interface that regulates
communication between the brain and blood. It is comprised of brain endothelial cells which …

Senescent microglia are a distinct microglial phenotype present in aging brain that have
been implicated in the progression of aging and age-related neurodegenerative diseases …

Background Microglial polarization is one of the most promising therapeutic targets for
multiple central nervous system (CNS) disorders, including ischemic stroke. However …

Microglia at the scene of the crime: what their transcriptom... : Current Opinion in Neurology
Microglia at the scene of the crime: what their transcriptomics reveal about brain health …

Powassan virus (POWV) is an emergent tick-borne flavivirus that causes fatal encephalitis in
the elderly and long-term neurologic sequelae in survivors. How age contributes to severe …

Beta (β)-galactosidase is a lysosomal enzyme that removes terminal galactose residues
from glycolipids and glycoproteins. It is upregulated in, and used as a marker for, senescent …