Poor sleep quality and disrupted circadian behavior are a normal part of aging and include
excessive daytime sleepiness, increased sleep fragmentation, and decreased total sleep …

Ischemic stroke (IS) is a fatal neurological disease that occurs when the blood flow to the
brain is disrupted, leading to brain tissue damage and functional impairment. Cellular …

Immuno-neurology is an emerging therapeutic strategy for dementia and neurodegeneration
designed to address immune surveillance failure in the brain. Microglia, as central nervous …

Powassan virus (POWV) is an emergent tick-borne flavivirus that causes fatal encephalitis in
the elderly and long-term neurologic sequelae in survivors. How age contributes to severe …

Background Microglia, the brain-resident macrophages perform immune surveillance and
engage with pathological processes resulting in phenotype changes necessary for …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease mainly
characterized by the accumulation of ubiquitinated proteins in the affected motor neurons. At …

Abstract Purpose of Review Multiple sclerosis (MS) is a chronic, immune-mediated
demyelinating disorder of the central nervous system. Age is one of the most important …

While primarily produced in the pineal gland, melatonin's influence goes beyond its well-
known role in regulating sleep, nighttime metabolism, and circadian rhythms, in the field of …

The COVID-19 pandemic imposed a series of behavioral changes that resulted in increased
social isolation and a more sedentary life for many across all age groups, but, above all, for …

Microglia, the resident immune cells of the central nervous system, are critically involved in
maintaining brain homeostasis. With age, microglia display morphological and functional …