Microglia and the aging brain: are geriatric microglia linked to poor sleep quality?
ME Choudhury, K Miyanishi, H Takeda… - International Journal of …, 2021 - mdpi.com
Poor sleep quality and disrupted circadian behavior are a normal part of aging and include
excessive daytime sleepiness, increased sleep fragmentation, and decreased total sleep …
excessive daytime sleepiness, increased sleep fragmentation, and decreased total sleep …
[HTML][HTML] Integrative analysis of single-cell and bulk RNA sequencing unveils the senescence landscape in ischemic stroke
L Fu, B Yu, Y Zhang, S Cao, B Lv, Y Tian… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Ischemic stroke (IS) is a fatal neurological disease that occurs when the blood flow to the
brain is disrupted, leading to brain tissue damage and functional impairment. Cellular …
brain is disrupted, leading to brain tissue damage and functional impairment. Cellular …
Targeting Progranulin as an Immuno-Neurology Therapeutic Approach
MA Boylan, A Pincetic, G Romano, N Tatton… - International Journal of …, 2023 - mdpi.com
Immuno-neurology is an emerging therapeutic strategy for dementia and neurodegeneration
designed to address immune surveillance failure in the brain. Microglia, as central nervous …
designed to address immune surveillance failure in the brain. Microglia, as central nervous …
Age-dependent Powassan virus lethality is linked to glial cell activation and divergent neuroinflammatory cytokine responses in a murine model
MC Mladinich, GE Himmler, JN Conde… - Journal of …, 2024 - journals.asm.org
Powassan virus (POWV) is an emergent tick-borne flavivirus that causes fatal encephalitis in
the elderly and long-term neurologic sequelae in survivors. How age contributes to severe …
the elderly and long-term neurologic sequelae in survivors. How age contributes to severe …
Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic …
Background Microglia, the brain-resident macrophages perform immune surveillance and
engage with pathological processes resulting in phenotype changes necessary for …
engage with pathological processes resulting in phenotype changes necessary for …
The Current Potential Pathogenesis of Amyotrophic Lateral Sclerosis
S Jiang, R Xu - Molecular Neurobiology, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease mainly
characterized by the accumulation of ubiquitinated proteins in the affected motor neurons. At …
characterized by the accumulation of ubiquitinated proteins in the affected motor neurons. At …
The Impact of Aging on Multiple Sclerosis
CE Goyne, AE Fair, PE Sumowski… - Current Neurology and …, 2024 - Springer
Abstract Purpose of Review Multiple sclerosis (MS) is a chronic, immune-mediated
demyelinating disorder of the central nervous system. Age is one of the most important …
demyelinating disorder of the central nervous system. Age is one of the most important …
The Vital Role of Melatonin and Its Metabolites in the Neuroprotection and Retardation of Brain Aging
While primarily produced in the pineal gland, melatonin's influence goes beyond its well-
known role in regulating sleep, nighttime metabolism, and circadian rhythms, in the field of …
known role in regulating sleep, nighttime metabolism, and circadian rhythms, in the field of …
Unwanted exacerbation of the Immune response in neurodegenerative disease: a Time to review the impact
AOF Leite, J Bento Torres Neto… - Frontiers in Cellular …, 2021 - frontiersin.org
The COVID-19 pandemic imposed a series of behavioral changes that resulted in increased
social isolation and a more sedentary life for many across all age groups, but, above all, for …
social isolation and a more sedentary life for many across all age groups, but, above all, for …
[HTML][HTML] Senescence and aging differentially alter key metabolic pathways in murine brain microglia
Microglia, the resident immune cells of the central nervous system, are critically involved in
maintaining brain homeostasis. With age, microglia display morphological and functional …
maintaining brain homeostasis. With age, microglia display morphological and functional …