While primarily produced in the pineal gland, melatonin's influence goes beyond its well-
known role in regulating sleep, nighttime metabolism, and circadian rhythms, in the field of …

Ischemic stroke remains a leading cause of global mortality and disability, with
neuroinflammation playing a critical role in determining patient outcomes. Microglia, the …

The COVID-19 pandemic imposed a series of behavioral changes that resulted in increased
social isolation and a more sedentary life for many across all age groups, but, above all, for …

Microglia, the resident immune cells of the central nervous system, are critically involved in
maintaining brain homeostasis. With age, microglia display morphological and functional …

Microglia, the resident immune‐competent cells of the brain, become dysfunctional in
Alzheimer's disease (AD), and their aberrant immune responses contribute to the …

The maintenance of genome stability is crucial for cell homeostasis and tissue integrity.
Numerous human neuropathologies display chronic inflammation in the central nervous …

The existing literature on neurodegenerative diseases (NDDs) reveals a common
pathological feature: the accumulation of misfolded proteins. However, the heterogeneity in …

Neuroinflammation and the underlying dysregulated immune responses of microglia actively
contribute to the progression and, likely, the initiation of Alzheimer's disease (AD). Fine …

Increase of age-related disabilities in our aging population constitutes a major
socioeconomic burden. Underlying mechanisms of motor, sensory and cognitive impairment …

Aging is the biggest risk factor for Parkinson's disease (PD) and a particular vulnerability of
dopaminergic neurons in the substantia nigra to aging-associated effects has been firmly …