Medicinal plants, phytochemicals and regulation of the NLRP3 inflammasome in inflammatory bowel diseases: A comprehensive review

R Direito, SM Barbalho, ME Figueira, G Minniti… - Metabolites, 2023 - mdpi.com
Ongoing research explores the underlying causes of ulcerative colitis and Crohn's disease.
Many experts suggest that dysbiosis in the gut microbiota and genetic, immunological, and …

Natural monoterpenes as potential therapeutic agents against atherosclerosis

J Yang, C Zhong, J Yu - International Journal of Molecular Sciences, 2023 - mdpi.com
Traditional herbal medicines based on natural products play a pivotal role in preventing and
managing atherosclerotic diseases, which are among the leading causes of death globally …

[HTML][HTML] Myeloid Ikaros–SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver

K Kadono, S Kageyama, K Nakamura, H Hirao, T Ito… - Journal of …, 2022 - Elsevier
Background & Aims Although Ikaros (IKZF1) is a well-established transcriptional regulator in
leukocyte lymphopoiesis and differentiation, its role in myeloid innate immune responses …

[HTML][HTML] Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2 …

W Zhang, W Wang, C Shen, X Wang, Z Pu… - Aging (Albany NY …, 2021 - ncbi.nlm.nih.gov
Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial
cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome - PMC …

Avenanthramide C from oats protects pyroptosis through dependent ROS-induced mitochondrial damage by PI3K ubiquitination and phosphorylation in pediatric …

Z Pu, C Shen, W Zhang, H Xie… - Journal of Agricultural and …, 2022 - ACS Publications
Oat containing rich β-glucan, polyphenols, flavonoids, saponins, alkaloids, and other
substances shows good biological activities. Therefore, the present study aimed to uncover …

Gallic acid ameliorates dextran sulfate sodium-induced ulcerative colitis in mice via inhibiting NLRP3 inflammasome

TY Yu, YM Feng, WS Kong, SN Li, XJ Sun… - Frontiers in …, 2023 - frontiersin.org
Background: Ulcerative colitis (UC) is a chronic recurrent inflammatory bowel disease (IBD).
The conventional drugs for UC may induce severe side effects. Herbal medicine is …

Atractylodes lancea Rhizoma Attenuates DSS-Induced Colitis by Regulating Intestinal Flora and Metabolites

L Qu, C Liu, C Ke, X Zhan, L Li, H Xu… - The American journal of …, 2022 - World Scientific
Atractylodes lancea (Thunb.) DC. is a herb widely used traditionally for the treatment of
gastrointestinal diseases such as gastric ulcer, spleen deficiency, and diarrhea. In China …

Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway

JL Pu, ZT Huang, YH Luo, T Mou, TT Li, ZT Li… - … & Pancreatic Diseases …, 2021 - Elsevier
Background Hepatic ischemia-reperfusion (I/R) injury (IRI) represents a crucial challenge in
liver transplantation. Fisetin has anti-inflammatory, anti-aging and anti-oxidative properties …

[HTML][HTML] The effects and mechanisms of the anti-COVID-19 traditional Chinese medicine, Dehydroandrographolide from Andrographis paniculata (Burm. f.) Wall, on …

Z Pu, B Sui, X Wang, W Wang, L Li, H Xie - Phytomedicine, 2023 - Elsevier
Abstract Background Dehydroandrographolide (Deh) from Andrographis paniculata (Burm.
f.) Wall has strong anti-inflammatory and antioxidant activities. Purpose To explore the role …

[Retracted] Human Umbilical Cord Mesenchymal Stem Cells Improve Premature Ovarian Failure through Cell Apoptosis of miR‐100‐5p/NOX4/NLRP3

J Niu, F Yu, X Luo, S Chen - BioMed Research International, 2022 - Wiley Online Library
Premature ovarian failure refers to a series of symptoms of perimenopausal hot flashes,
night sweats, decreased libido, vaginal dryness, insomnia, reduced menstruation, sparse …