Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …

Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times.
They have enjoyed over 30 years of clinical usage and become essential tools in the …

Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …

Topoisomerases are ubiquitous enzymes that control DNA supercoiling and entanglements.
They are essential during transcription and replication, and topoisomerase inhibitors are …

DNA topoisomerases are the targets of important anticancer and antibacterial drugs.
Camptothecins and novel noncamptothecins in clinical development (indenoisoquinolines …

Recent molecular studies have expanded the biological contexts in which topoisomerase II
(TOP2) has crucial functions, including DNA replication, transcription and chromosome …

Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood
glucose levels within a narrow range. Caloric restriction causes many changes in glucose …

Abstract Nuclear DNA topoisomerase I (TOP1) is an essential human enzyme. It is the only
known target of the alkaloid camptothecin, from which the potent anticancer agents …

TDP1 and TDP2 were discovered and named based on the fact they process 3′-and 5′-
DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases …

DNA topoisomerases I and II (Top1 and Top2) are established molecular targets of
anticancer drugs. 1-5 Mammalian somatic cells express six topoisomerase genes: two TOP1 …