Polyunsaturated fatty acids-induced ferroptosis suppresses pancreatic cancer growth
A Suda, BA Umaru, Y Yamamoto, H Shima, Y Saiki… - Scientific Reports, 2024 - nature.com
Despite recent advances in science and medical technology, pancreatic cancer remains
associated with high mortality rates due to aggressive growth and no early clinical sign as …
associated with high mortality rates due to aggressive growth and no early clinical sign as …
Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American …
Abstract Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical
roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 …
roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 …
Assessment of causal relationships between omega-3 and omega-6 polyunsaturated fatty acids in autoimmune rheumatic diseases: a brief research report from a …
X Xu, X Xu, MA Zakeri, SY Wang, M Yan… - Frontiers in …, 2024 - frontiersin.org
Background Currently, the association between the consumption of polyunsaturated fatty
acids (PUFAs) and the susceptibility to autoimmune rheumatic diseases (ARDs) remains …
acids (PUFAs) and the susceptibility to autoimmune rheumatic diseases (ARDs) remains …
Crosstalk Between the Nervous System and Colorectal Cancer
X Li, C Ye, M Wang, P Kwan, X Tian, Y Zhang - Neuroscience Bulletin, 2024 - Springer
The nervous system is the dominant regulatory system in the human body. The traditional
theory is that tumors lack innervation. However, an increasing number of studies have …
theory is that tumors lack innervation. However, an increasing number of studies have …
Integrative polygenic analysis of the protective effects of fatty acid metabolism on disease as modified by obesity
Dysregulation of fatty acid metabolites can play a crucial role in the progression of complex
diseases, such as cardiovascular disease, digestive diseases, and metabolic diseases …
diseases, such as cardiovascular disease, digestive diseases, and metabolic diseases …
Identifying metabolic features of colorectal cancer liability using Mendelian randomization
Background: Recognizing the early signs of cancer risk is vital for informing prevention, early
detection, and survival. Methods: To investigate whether changes in circulating metabolites …
detection, and survival. Methods: To investigate whether changes in circulating metabolites …
A prognostic model for hepatocellular carcinoma patients based on polyunsaturated fatty acid‐related genes
Y Lin, R Li, T Li, W Zhao, Q Ye, C Dong… - Environmental …, 2024 - Wiley Online Library
Abstract Objective Polyunsaturated fatty acids (PUFAs) have attracted increasing attention
for their role in liver cancer development. The objective of this study is to develop a …
for their role in liver cancer development. The objective of this study is to develop a …
[HTML][HTML] Fatty acid desaturase insertion-deletion polymorphism rs66698963 predicts colorectal polyp prevention by the n-3 fatty acid eicosapentaenoic acid: A …
G Sun, YN Li, JR Davies, RC Block… - The American Journal of …, 2024 - Elsevier
Background A fatty acid desaturase (FADS) insertion-deletion (Indel) polymorphism
(rs66698963) influences expression of FADS1, which controls synthesis of n-6 highly …
(rs66698963) influences expression of FADS1, which controls synthesis of n-6 highly …
Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK
F Guo, G Ling, J Qiu, J Li, Y Gan, YY Yu, J Tang, L Mo… - Chinese Medicine, 2024 - Springer
Background Ferroptosis, a non-apoptotic form of cell death induced by accumulation of free
iron ions and lipid peroxidation, its importance for cancer treatment is gradually being …
iron ions and lipid peroxidation, its importance for cancer treatment is gradually being …
Assessments of dietary intake and polygenic risk score in associations with colorectal cancer risk: evidence from the UK Biobank
Background This study aimed to explore the potential interaction between dietary intake and
genetics on incident colorectal cancer (CRC) and whether adherence to healthy dietary …
genetics on incident colorectal cancer (CRC) and whether adherence to healthy dietary …