Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities
X Jiang, K Wu, R Bai, P Zhang, Y Zhang - European Journal of Medicinal …, 2022 - Elsevier
Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …
Pharmacological profile of quinoxalinone
Y Ramli, A Moussaif, K Karrouchi… - Journal of …, 2014 - Wiley Online Library
Quinoxalinone and its derivatives are used in organic synthesis for building natural and
designed synthetic compounds and they have been frequently utilized as suitable skeletons …
designed synthetic compounds and they have been frequently utilized as suitable skeletons …
Reversal of the multidrug resistance of human ileocecal adenocarcinoma cells by acetyl-11-keto-β-boswellic acid via downregulation of P-glycoprotein signals
X Xue, F Chen, A Liu, D Sun, J Wu, F Kong… - BioScience …, 2016 - jstage.jst.go.jp
Multidrug resistance (MDR) represents a clinical obstacle to cancer chemotherapy since it
causes cancer recurrence and metastasis. Acetyl-11-keto-β-boswellic acid (AKBA), an active …
causes cancer recurrence and metastasis. Acetyl-11-keto-β-boswellic acid (AKBA), an active …
[HTML][HTML] Crystal structure, Hirshfeld surface analysis and DFT study of 1-ethyl-3-phenyl-1, 2-dihydroquinoxalin-2-one
G Al Ati, K Chkirate, A Mashrai, JT Mague… - Acta Crystallographica …, 2021 - scripts.iucr.org
In the title molecule, C16H14N2O, the dihydroquinoxaline moiety is not planar as there is a
dihedral angle of 4.51 (5)° between the constituent rings. In the crystal, C—H⋯ O hydrogen …
dihedral angle of 4.51 (5)° between the constituent rings. In the crystal, C—H⋯ O hydrogen …
草珊瑚化学成分的研究
郑学芳， 刘海洋， 钟惠民 - 天然产物研究与开发, 2014 - trcw.ac.cn
采用硅胶, Sephadex LH-20, MCI 等方法从草珊瑚(Sarcandra glabra) 全草乙酸乙酯萃取部位
分离得到10 个化合物, 经波谱学方法鉴定为Chlorajapolide C (1), Shizukanolide H (2) …
分离得到10 个化合物, 经波谱学方法鉴定为Chlorajapolide C (1), Shizukanolide H (2) …
Modulation of P-glycoprotein activity by the substituted quinoxalinone compound QA3 in adriamycin-resistant K562/A02 cells
LR Sun, JL Zhong, SX Cui, X Li, SG Ward, YQ Shi… - Pharmacological …, 2010 - Springer
QA3 is a derivative of the substituted 1, 3-dimethyl-1H-quinoxalin-2-ones, which are
compounds that may selectively antagonize P-glycoprotein (P-gp) in multidrug resistance …
compounds that may selectively antagonize P-glycoprotein (P-gp) in multidrug resistance …
Synthesis, crystal structure and Hirshfeld surface analysis of 1-[3-(2-oxo-3-phenyl-1, 2-dihydroquinoxalin-1-yl) propyl]-3-phenyl-1, 2-dihydroquinoxalin-2-one
N Abad, JT Mague, A Alsubari, EM Essassi… - Acta …, 2024 - journals.iucr.org
In the title compound, C31H24N4O2, the dihydroquinoxaline units are both essentially
planar with the dihedral angle between their mean planes being 64.82 (4) . The attached …
planar with the dihedral angle between their mean planes being 64.82 (4) . The attached …
Inhibitiory properties of cytoplasmic extract of Lactobacilli isolated from common carp intestine on human chronic myelocytic leukemia K562 cell line: an in vitro study.
F Kabiri, V Nejati, A Tukmechi… - Tehran University …, 2011 - search.ebscohost.com
Background: Lactobacillus species are genetically diverse groups of Lactic Acid Bacteria
(LAB) that have been introduced as probiotics, because of some characteristics such as their …
(LAB) that have been introduced as probiotics, because of some characteristics such as their …
Effect of phorbol 12-myristate 13-acetate on function and gene expression of P-glycoprotein in adriamycin-resistant K562/ADM cells
Y Li, H Bi, G Zhong, L Huang, G Li, Y Xia, X Chen… - Pharmacology, 2013 - karger.com
Background/Aims: Multidrug resistance (MDR) is a critical issue during chemotherapy of
cancers. Phorbol 12-myristate 13-acetate (PMA), a diester of phorbol, is a typical activator of …
cancers. Phorbol 12-myristate 13-acetate (PMA), a diester of phorbol, is a typical activator of …
冬凌草活性部位逆转SGC7901/ADR 细胞多药耐药性的体外研究
高巧慧， 许文婷， 谢婷， 刘瑞媛， 吴臻， 李发荣 - 天然产物研究与开发, 2014 - cqvip.com
以SGC7901 和SGC7901/ADR 为细胞模型, 检测了冬凌草活性部位与化疗药物联用后,
对SGC7901/ADR 耐药性的逆转效应; 冬凌草活性部位处理细胞后, 检测耐药细胞内阿霉素的 …
对SGC7901/ADR 耐药性的逆转效应; 冬凌草活性部位处理细胞后, 检测耐药细胞内阿霉素的 …