Background Pin1 is an intracellular signaling molecule which plays a critical but opposite
role in the pathogenesis of Alzheimer's disease (AD) and many human cancers. Scope of …

Multiple genetic, metabolic, and environmental abnormalities are known to contribute to the
pathogenesis of Alzheimer's dementia (AD). If all of those abnormalities were addressed it …

The Apolipoprotein E (APOE) locus has garnered significant clinical interest because of its
association with Alzheimer's disease (AD) and longevity. This genetic association appears …

Mitochondrial dysfunctions significantly contribute to the pathogenesis of Alzheimer's
disease (AD). Here, we studied the relationship between AD and changes in the …

Cognitive impairment is commonly found in the elderly population. Evidence suggests that
mitochondrial function in lymphocytes are potential biomarkers in the progression of …

The deposition of amyloid-β (Aβ) peptides in senile plaques is one of pathological hallmarks
of Alzheimer's disease (AD). Mitochondrial dysfunction is an early event of cell apoptosis …

Background Synaptic dysfunction is a major contributor to Alzheimeŕs disease (AD)
pathogenesis in addition to the formation of neuritic β-amyloid plaques and neurofibrillary …

Brain decoding, aiming to identify the brain states using neural activity, is important for
cognitive neuroscience and neural engineering. However, existing machine learning …

Dysregulated Wnt signaling is linked to major neurodegenerative diseases, including
Alzheimer disease (AD). In mouse models of AD, activation of the canonical Wnt signaling …

Aim: We investigated the effect and mechanism of Icariin (ICA) on improving
neurobehavioral ability of mice with Alzheimer's disease (AD). Methods: We selected 10 …