Background Parkinson's disease is the second most common neurodegenerative disease in
the world. However, current diagnostic methods are still limited, and available treatments …

Communication between astrocytes and neurons has a profound effect on the
pathophysiology of Alzheimer's disease (AD). Astrocytes regulate homeostasis and increase …

Dysfunctions in liver metabolic activities may increase the risk of cognitive impairment and
dementia. In a cohort of community-dwelling older persons investigated for a suspected …

Proline is an amino acid with an essential role for primary metabolism and physiologic
functions. Hyperprolinemia results from the deficiency of specific enzymes for proline …

Background Mild cognitive impairment (MCI) is a neurocognitive state between normal
cognitive aging and dementia, with evidence of neuropsychological changes but insufficient …

Synapse impairment in the Alzheimer's disease (AD) brain is an early event leading to
cognitive dysfunction. Most oxidative stress localizes to the synapse, and synapse loss is the …

The global increase in the aging population has led to a rise in many age-related diseases
with continuing unmet therapeutic needs. Research into the molecular mechanisms …

An essential feature of Alzheimer's disease (AD) is implicated in brain energy metabolic
impairment that is considered underlying pathogenesis of cognitive impairment. Therefore …

Brain plasticity and metabolism are tightly connected by a constant influx of peripheral
glucose to the central nervous system in order to meet the high metabolic demands imposed …

Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most
studies of the effects of stress in models of AD utilize acute adverse stressors of …