Most of the previous task functional magnetic resonance imaging (fMRI) studies found
abnormalities in distributed brain regions in mild cognitive impairment (MCI) and Alzheimer's …

Inflammation is an organism's biological defense mechanism. Acute and chronic
inflammation of the body triggers the production of pro-and anti-inflammatory pathways that …

Objective: To determine whether metformin is associated with a lower incidence of dementia
than sulfonylureas. Methods: This was a retrospective cohort study of US veterans≥ 65 …

Impaired brain energy metabolism and oxidative stress are implicated in cognitive decline
and the pathologic accumulations of amyloid β-peptide (Aβ) and hyperphosphorylated tau in …

Aging is a physiological process that can develop without the appearance of concurrent
diseases. However, very frequently, older people suffer from memory loss and an …

Precision medicine can be defined as the prevention, investigation and treatment of
diseases taking individual variability into account. There are multiple ways in which the field …

Amyloid-β (Aβ) oligomers have been accepted as major neurotoxic agents in the therapy of
Alzheimer's disease (AD). It has been shown that the activity of nicotinamide adenine …

The epidemic and experimental studies have confirmed that the obesity can lead to
neuroinflammation, neurodegenerative diseases and adversely affect cognition. Despite the …

Neurodegenerative diseases are disorders that are characterized by a progressive decline
of motor and/or cognitive functions caused by the selective degeneration and loss of …

In sporadic age-related forms of Alzheimer's disease (AD), it is unclear why amyloid-β (Aβ)
peptides accumulate. Here we show that soluble amyloid precursor protein-α (sAPP-α) …