In sporadic age-related forms of Alzheimer's disease (AD), it is unclear why amyloid-β (Aβ)
peptides accumulate. Here we show that soluble amyloid precursor protein-α (sAPP-α) …

The epidemic and experimental studies have confirmed that the obesity can lead to
neuroinflammation, neurodegenerative diseases and adversely affect cognition. Despite the …

Background The ketogenic diet (KD) has been used in treatment-resistant epilepsy since the
1920s. It has been researched in a variety of neurological conditions in both animal models …

Introduction/aim The brain in Alzheimer's disease shows glucose hypometabolism but may
utilize ketones for energy production. Ketone levels can potentially be boosted through oral …

Currently, there are no disease-modifying treatments for Alzheimer's disease (AD) or any
other dementia subtype. The renaissance in psychedelic research in recent years, in …

Neurodegenerative diseases (NDs) are one of the major health threats to human
characterized by selective and progressive neuronal loss. The mechanisms of NDs are still …

Mitochondria are the double membrane organelles providing most of the energy for cells. In
addition, mitochondria also play essential roles in various cellular biological processes such …

Brain-derived neurotrophic factor (BDNF) promotes the survival and growth of neurons
during brain development and mediates activity-dependent synaptic plasticity and …

Alzheimer's disease (AD) is a chronic, complex neurodegenerative disorder mainly
characterized by the irreversible loss of memory and cognitive functions. Different …

Citrate synthase is a key mitochondrial enzyme that utilizes acetyl-CoA and oxaloacetate to
form citrate in the mitochondrial membrane, which participates in energy production in the …