Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …

Although, the nucleolus has been observed for almost 200 years in neurons, studies that
directly address the neuronal roles of this subnuclear structure have appeared only recently …

The unique vulnerability of the olfactory system to Alzheimer's disease (AD) provides a
quintessential translational tool for understanding mechanisms of synaptic dysfunction and …

Apolipoprotein E (ApoE) plays multiple roles in lipid transport, neuronal signaling, glucose
metabolism, mitochondrial function, and inflammation in the brain. It is also associated with …

Alzheimer's disease (AD) is the most common neurocognitive disorder and a global health
problem. The prevalence of AD is growing dramatically, especially in low‐and middle …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

Mitochondria are the primary source of energy production in the brain thereby supporting
most of its activity. However, mitochondria become inefficient and dysfunctional with age and …

Impaired synaptic plasticity is implicated in the functional decline of the nervous system
associated with ageing. Understanding the structure of ageing synapses is essential to …

In this perspective we list the many clinical, histopathological, genetic and chemical
observations relating copper to Alzheimer's disease (AD). We summarize how the …

Human performance, endurance, and resilience have biological limits that are genetically
and epigenetically predetermined but perhaps not yet optimized. There are few systematic …