Antibiofilm activity of host defence peptides: Complexity provides opportunities

REW Hancock, MA Alford, EF Haney - Nature Reviews Microbiology, 2021 - nature.com
Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …

Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era

J Wang, X Dou, J Song, Y Lyu, X Zhu… - Medicinal research …, 2019 - Wiley Online Library
Antimicrobial peptides (AMPs), critical components of the innate immune system, are widely
distributed throughout the animal and plant kingdoms. They can protect against a broad …

[HTML][HTML] Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds

A Pfalzgraff, K Brandenburg, G Weindl - Frontiers in pharmacology, 2018 - frontiersin.org
Alarming data about increasing resistance to conventional antibiotics are reported, while at
the same time the development of new antibiotics is stagnating. Skin and soft tissue …

[HTML][HTML] Mechanisms and consequences of bacterial resistance to antimicrobial peptides

DI Andersson, D Hughes… - Drug Resistance Updates, 2016 - Elsevier
Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …

Antimicrobial peptide structure and mechanism of action: a focus on the role of membrane structure

TH Lee, KN Hall, MI Aguilar - Current topics in medicinal …, 2016 - ingentaconnect.com
Antimicrobial peptides (AMPs) are showing increasing promise as potential candidate
antibacterial drugs in the face of the rapidly emerging bacterial resistance to conventional …

Neutrophils and bacterial immune evasion

SD Kobayashi, N Malachowa, FR DeLeo - Journal of innate immunity, 2018 - karger.com
Neutrophils are an important component of the innate immune system and provide a front
line of defense against bacterial infection. Although most bacteria are killed readily by …

Tetrahedral framework nucleic acids deliver antimicrobial peptides with improved effects and less susceptibility to bacterial degradation

Y Liu, Y Sun, S Li, M Liu, X Qin, X Chen, Y Lin - Nano letters, 2020 - ACS Publications
Antimicrobial peptides (AMPs) have been an attractive alternative to traditional antibiotics.
However, considerable efforts are needed to further enhance their antimicrobial effects and …

Environmental and genetic modulation of the phenotypic expression of antibiotic resistance

D Hughes, DI Andersson - FEMS microbiology reviews, 2017 - academic.oup.com
Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene,
and generally an acquired mechanism results in a predictable increase in phenotypic …

[HTML][HTML] Developing antimicrobial synergy with AMPs

L Duong, SP Gross, A Siryaporn - Frontiers in medical technology, 2021 - frontiersin.org
Antimicrobial peptides (AMPs) have been extensively studied due to their vast natural
abundance and ability to kill microbes. In an era critically lacking in new antibiotics …

Antimicrobial peptide synergies for fighting infectious diseases

JT Mhlongo, AY Waddad, F Albericio… - Advanced …, 2023 - Wiley Online Library
Antimicrobial peptides (AMPs) are essential elements of thehost defense system.
Characterized by heterogenous structures and broad‐spectrumaction, they are promising …