Synthetic and materials chemistry initiatives have enabled the translation of the
macromolecular functions of biology into synthetic frameworks. These explorations into …

Several different non-enzymatic molecular replication systems have been prepared and
analyzed, including nucleic acids, fatty acids, peptides, and organic molecules.[1–11] This …

We have been studying simple prebiotic catalytic replicating networks as prototypes for
modeling replication, complexification and Systems Chemistry. While living systems are …

An emerging new direction of research focuses on developing “self-synthesizing materials”,
those supramolecular structures that can promote their own formation by accelerating the …

Can we emulate nature's technology in chemistry? Through billions of years of evolution,
Nature has generated some remarkable systems and substances that have made life on …

Living organisms often display rhythmic and oscillatory behavior. We investigate here a
challenge in contemporary Systems Chemistry, that is, to construct “bottom-up” molecular …

Most self-replicating peptide systems are made of α-helix forming sequences. However, it
has been postulated that shorter and simpler peptides may also serve as templates for …

A molecular network that mimics circadian clocks from cyanobacteria is constructed in silico.
Simulating its oscillatory behaviour under variable conditions reveals its robustness relative …

Synthetic structures capable of autocatalysis based on molecular recognition–self-
replication–were introduced nearly 20 years ago. These systems involved neither …

Perhaps the most important feature of Nature is the sheer and overwhelming complexity of
biological systems. Life as we know it involves a staggering array of biochemical entities that …