Perineural invasion (PNI), the neoplastic invasion of nerves, is a common pathologic finding
in head and neck cancer that is associated with poor clinical outcomes. PNI is a histologic …

Perineural invasion (PNI) is a mechanism of tumor dissemination that can provide a
challenge to tumor eradication and that is correlated with poor survival. Squamous cell …

PURPOSE The aim of the current work is to provide evidence-based recommendations to
practicing physicians and others on the management of the neck in patients with squamous …

Despite early diagnosis and treatment, almost 20% of patients with early-stage (cT1-cT2N0)
oral tongue squamous cell carcinoma (OTSCC) still die of their disease. The prognosis of …

Objectives Depth of invasion (DOI) is the most important predictor for lymph node metastasis
(LNM) in early stage (T1-T2) oral cancer. The aim of this study is to validate the cut-off value …

Objectives Tumour relapse remains one of the major problems in managing oral squamous
cell carcinoma (OSCC) with mortality rates of up to 92%. Early recurrences have a worse …

Aims One of the objectives of current research is to customise the treatment of cancer
patients. The achievement of this objective requires stratification of patients based on the …

Purpose The role of perineural invasion (PNI) in the management of patients with oral
squamous cell carcinoma (OSSC) is still controversial, and there is no consensus regarding …

Methods A literature review was carried out, searching the MedLine databases via Pubmed,
Scielo, Lilacs, Cochrane and Websco. Results A total of 56 studies were included. The …

Simple Summary Squamous cell carcinoma is the most common type of oral cavity cancer. It
can spread along and invade nerves in a process called perineural invasion. Perineural …