The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

The authors define molecular imaging, according to the Society of Nuclear Medicine and
Molecular Imaging, as the visualization, characterization, and measurement of biological …

Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars,
are very commonly used in biomedical imaging and cancer therapy. They make excellent …

Metabolic magnetic resonance imaging (MRI) using hyperpolarized (HP) pyruvate is
becoming a non‐invasive technique for diagnosing, staging, and monitoring response to …

The tumour microenvironment is of critical importance in cancer development and
progression and includes the surrounding stromal and immune cells, extracellular matrix …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Hyperpolarized fumarate is a promising biosensor for carbon-13 magnetic resonance
metabolic imaging. Such molecular imaging applications require nuclear hyperpolarization …

N-acetylcysteine (NAC) has been used as a direct scavenger of reactive oxygen species
(hydrogen peroxide, in particular) and an antioxidant in cancer biology and immuno …

Carbon-13 hyperpolarized pyruvate is about to become the next-generation contrast agent
for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient and …

Dynamic nuclear polarization (DNP) is a widely used tool for overcoming the low intrinsic
sensitivity of nuclear magnetic resonance spectroscopy and imaging. Its practical …