The activation mechanism of the insulin receptor: a structural perspective

E Choi, XC Bai - Annual review of biochemistry, 2023 - annualreviews.org
The insulin receptor (IR) is a type II receptor tyrosine kinase that plays essential roles in
metabolism, growth, and proliferation. Dysregulation of IR signaling is linked to many human …

Neuroinflammation pathways: a general review

T Shabab, R Khanabdali… - International Journal …, 2017 - Taylor & Francis
Activated microglial cells play an important role in immune and inflammatory responses in
central nervous system and neurodegenerative diseases. Many pro-apoptotic pathways are …

[HTML][HTML] Mycotoxin occurrence, toxicity, and detoxifying agents in pig production with an emphasis on deoxynivalenol

DM Holanda, SW Kim - Toxins, 2021 - mdpi.com
This review aimed to investigate the occurrence of mycotoxins, their toxic effects, and the
detoxifying agents discussed in scientific publications that are related to pig production …

Toxicology of deoxynivalenol and its acetylated and modified forms

D Payros, I Alassane-Kpembi, A Pierron, N Loiseau… - Archives of …, 2016 - Springer
Mycotoxins are the most frequently occurring natural contaminants in human and animal
diet. Among them, deoxynivalenol (DON), produced by Fusarium, is one of the most …

Dual‐specificity MAP kinase phosphatases (MKPs) Shaping the outcome of MAP kinase signalling

CJ Caunt, SM Keyse - The FEBS journal, 2013 - Wiley Online Library
Dual‐specificity MAP kinase phosphatases (MKPs) provide a complex negative regulatory
network that acts to shape the duration, magnitude and spatiotemporal profile of MAP kinase …

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

G Pearson, F Robinson, T Beers Gibson, B Xu… - Endocrine …, 2001 - academic.oup.com
Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed,
protein-serine/threonine kinases, which participate in signal transduction pathways that …

[HTML][HTML] Insulin receptor endocytosis in the pathophysiology of insulin resistance

C Hall, H Yu, E Choi - Experimental & molecular medicine, 2020 - nature.com
Insulin signaling controls cell growth and metabolic homeostasis. Dysregulation of this
pathway causes metabolic diseases such as diabetes. Insulin signaling pathways have …

Mechanisms of photoaging and chronological skin aging

GJ Fisher, S Kang, J Varani, Z Bata-Csorgo… - Archives of …, 2002 - jamanetwork.com
Human skin, like all other organs, undergoes chronological aging. In addition, unlike other
organs, skin is in direct contact with the environment and therefore undergoes aging as a …

Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

M Mehta, DS Dhanjal, KR Paudel, B Singh… - …, 2020 - Springer
Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …

MAP kinases

Z Chen, TB Gibson, F Robinson, L Silvestro… - Chemical …, 2001 - ACS Publications
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