Therapeutic modulation of endogenous gene function by agents with designed DNA‐sequence specificities
Designer molecules that can specifically target pre‐determined DNA sequences provide a
means to modulate endogenous gene function. Different classes of sequence‐specific DNA …
means to modulate endogenous gene function. Different classes of sequence‐specific DNA …
Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma
Purpose Survivin, a member of the inhibitor of apoptosis (IAP) family, is not detected in
normal adult tissues but is overexpressed in various cancers, including some types of …
normal adult tissues but is overexpressed in various cancers, including some types of …
Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer
K Krysan, H Dalwadi, S Sharma, M Pold, S Dubinett - Cancer research, 2004 - AACR
Abstract Elevated tumor cyclooxygenase 2 (COX-2) expression is associated with increased
angiogenesis, tumor invasion, and promotion of tumor cell resistance to apoptosis. In our …
angiogenesis, tumor invasion, and promotion of tumor cell resistance to apoptosis. In our …
Augmented anticancer efficacy by si-RNA complexed drug-loaded mesoporous silica nanoparticles in lung cancer therapy
F Dilnawaz, SK Sahoo - ACS Applied Nano Materials, 2018 - ACS Publications
Lung cancer remains the major cause of death throughout the world. However, with the
cutting-edge therapeutic approaches the patient's survivability remains poor. Nanoparticle …
cutting-edge therapeutic approaches the patient's survivability remains poor. Nanoparticle …
Effect of hypoxia-inducible factor-1α on transcription of survivin in non-small cell lung cancer
YQ Chen, CL Zhao, W Li - Journal of Experimental & Clinical Cancer …, 2009 - Springer
Background Survivin is a structurally and functionally unique member of the inhibitor of
apoptosis protein (IAP) family. It plays an important role, not only in regulating mitosis but …
apoptosis protein (IAP) family. It plays an important role, not only in regulating mitosis but …
Sanguinarine suppresses prostate tumor growth and inhibits survivin expression
M Sun, W Lou, JY Chun, DS Cho… - Genes & …, 2010 - journals.sagepub.com
Prostate cancer is a frequently occurring disease and is the second leading cause of cancer-
related deaths of men in the United States. Current treatments have proved inadequate in …
related deaths of men in the United States. Current treatments have proved inadequate in …
Biomedical nanotechnology for cancer
A Pope-Harman, MMC Cheng, F Robertson… - Medical Clinics of North …, 2007 - Elsevier
Nanotechnology may hold the key to controlling many devastating diseases. In the fight
against the pain, suffering, and death due to cancer, nanotechnology will allow earlier …
against the pain, suffering, and death due to cancer, nanotechnology will allow earlier …
Molecular mechanism of inhibition of survivin transcription by the GC-rich sequence-selective DNA binding antitumor agent, hedamycin: evidence of survivin down …
J Wu, X Ling, D Pan, P Apontes, L Song, P Liang… - Journal of Biological …, 2005 - ASBMB
Expression of the antiapoptotic protein survivin is associated with cancer cell viability and
drug resistance. Thus, control of its expression in cancer cells has significant consequences …
drug resistance. Thus, control of its expression in cancer cells has significant consequences …
Structure of triplex DNA in the gas phase
Extensive (more than 90 microseconds) molecular dynamics simulations complemented
with ion-mobility mass spectrometry experiments have been used to characterize the …
with ion-mobility mass spectrometry experiments have been used to characterize the …
Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs
A Ohkubo, K Yamada, Y Ito, K Yoshimura… - Nucleic Acids …, 2015 - academic.oup.com
A triplex-forming oligonucleotide (TFO) could be a useful molecular tool for gene therapy
and specific gene modification. However, unmodified TFOs have two serious drawbacks …
and specific gene modification. However, unmodified TFOs have two serious drawbacks …