Designer molecules that can specifically target pre‐determined DNA sequences provide a
means to modulate endogenous gene function. Different classes of sequence‐specific DNA …

Purpose Survivin, a member of the inhibitor of apoptosis (IAP) family, is not detected in
normal adult tissues but is overexpressed in various cancers, including some types of …

Abstract Elevated tumor cyclooxygenase 2 (COX-2) expression is associated with increased
angiogenesis, tumor invasion, and promotion of tumor cell resistance to apoptosis. In our …

Lung cancer remains the major cause of death throughout the world. However, with the
cutting-edge therapeutic approaches the patient's survivability remains poor. Nanoparticle …

Background Survivin is a structurally and functionally unique member of the inhibitor of
apoptosis protein (IAP) family. It plays an important role, not only in regulating mitosis but …

Prostate cancer is a frequently occurring disease and is the second leading cause of cancer-
related deaths of men in the United States. Current treatments have proved inadequate in …

Nanotechnology may hold the key to controlling many devastating diseases. In the fight
against the pain, suffering, and death due to cancer, nanotechnology will allow earlier …

Expression of the antiapoptotic protein survivin is associated with cancer cell viability and
drug resistance. Thus, control of its expression in cancer cells has significant consequences …

Extensive (more than 90 microseconds) molecular dynamics simulations complemented
with ion-mobility mass spectrometry experiments have been used to characterize the …

A triplex-forming oligonucleotide (TFO) could be a useful molecular tool for gene therapy
and specific gene modification. However, unmodified TFOs have two serious drawbacks …