Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease and
disability in the elderly; it is estimated to account for 60%–70% of all cases of dementia …

Background Previously, we showed that the sphingosine-1-phosphate (S1P) transporter
spinster 2 (Spns2) mediates activation of microglia in response to amyloid β peptide (Aβ) …

The increasing life expectancy has led to a higher incidence of age-related
neurodegenerative conditions. Within this framework, neuroinflammation emerges as a …

Neuroinflammation refers to a highly complicated reaction of the central nervous system
(CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a …

Resveratrol is a natural phenolic compound with known benefits against
neurodegeneration. We analyzed in vitro the protective mechanisms of resveratrol against …

Background The incessant communication that takes place between microglia and neurons
is essential the development, maintenance, and pathogenesis of the central nervous system …

Growing evidence supports the suggestion that the peripheral immune system plays a role
in different pathologies associated with cognitive impairment, such as vascular dementia …

Osteoporosis is a common chronic metabolic bone disorder. Recently, increasing numbers
of studies have demonstrated that Toll-like receptor 4 (TLR4, a receptor located on the …

Abstract Ethnopharmacological relevance Qinzhizhudan Formula (QZZD) is composed of
Scutellaria baicalensis Georgi (Huang Qin) extract, Gardenia jasminoides (Zhizi) extract and …