Lipoprotein (a) and its significance in cardiovascular disease: a review

FD Lau, RP Giugliano - JAMA cardiology, 2022 - jamanetwork.com
Importance Lipoprotein (a)(Lp [a]) is a low-density lipoprotein (LDL) cholesterol–like particle
bound to apolipoprotein (a). This novel marker of cardiovascular disease acts through …

Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update

D Pantazi, C Tellis, AD Tselepis - Biofactors, 2022 - Wiley Online Library
Inflammation and oxidative stress conditions lead to a variety of oxidative modifications of
lipoprotein phospholipids implicated in the occurrence and development of atherosclerotic …

[HTML][HTML] Study design and rationale for the Olpasiran trials of Cardiovascular Events And lipoproteiN (a) reduction-DOSE finding study (OCEAN (a)-DOSE)

ML O'Donoghue, JAG López, B Knusel, B Gencer… - American Heart …, 2022 - Elsevier
Background Data support lipoprotein (a)(Lp [Lp (a)]) being a risk factor for atherosclerotic
cardiovascular disease (ASCVD). Olpasiran is a small interfering RNA molecule that …

Treatment and prevention of lipoprotein (a)-mediated cardiovascular disease: the emerging potential of RNA interference therapeutics

DI Swerdlow, DA Rider, A Yavari… - Cardiovascular …, 2022 - academic.oup.com
Lipid-and lipoprotein-modifying therapies have expanded substantially in the last 25 years,
resulting in reduction in the incidence of major adverse cardiovascular events. However, no …

[HTML][HTML] Novel pharmacological therapies for the management of hyperlipoproteinemia (a)

CE Kosmas, MD Bousvarou… - International Journal of …, 2023 - mdpi.com
Lipoprotein (a)[Lp (a)] is a well-established risk factor for cardiovascular disease,
predisposing to major cardiovascular events, including coronary heart disease, stroke, aortic …

[HTML][HTML] Treatment of Lp (a): is it the future or are we ready today?

AD Tselepis - Current Atherosclerosis Reports, 2023 - Springer
Abstract Purpose of Review The goal of this review is to present the pharmacodynamic
effectiveness as well as the clinical efficacy and safety of investigational antisense …

[HTML][HTML] Lipoprotein (a)—60 years later—what do we know?

A Pasławska, PJ Tomasik - Cells, 2023 - mdpi.com
Lipoprotein (a)(Lp (a)) molecule includes two protein components: apolipoprotein (a) and
apoB100. The molecule is the main transporter of oxidized phospholipids (OxPL) in plasma …

Residual cardiovascular risk: When should we treat it?

F Gomez-Delgado, M Raya-Cruz, N Katsiki… - European Journal of …, 2023 - Elsevier
Cardiovascular disease (CVD) still being the most common cause of death in worldwide. In
spite of development of new lipid-lowering therapies which optimize low-density lipoprotein …

[HTML][HTML] Lipoprotein (a) as a risk factor for cardiovascular diseases: pathophysiology and treatment perspectives

P Vinci, FG Di Girolamo, E Panizon, LM Tosoni… - International journal of …, 2023 - mdpi.com
Cardiovascular disease (CVD) is still a leading cause of morbidity and mortality, despite all
the progress achieved as regards to both prevention and treatment. Having high levels of …

[HTML][HTML] Proteins found in the triple-negative breast cancer secretome and their therapeutic potential

PR McHenry, JR Prosperi - International Journal of Molecular Sciences, 2023 - mdpi.com
The cancer secretome comprises factors secreted by tumors, including cytokines, growth
factors, proteins from the extracellular matrix (ECM), proteases and protease inhibitors …