Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or
heme and also several unrelated xenobiotics/chemicals. They reside in the plasma …

Acquisition of developmental competence is a complex process in which many cell types
cooperate to support oocyte maturation, fertilisation, and preimplantation embryonic …

Progesterone receptor membrane component 1 (PGRMC1) binds heme via a surface-
exposed site and displays some structural resemblance to cytochrome b5 despite their …

Membrane contact sites (MCSs) between endosomes and the endoplasmic reticulum (ER)
are thought to act as specialized trigger zones for Ca 2+ signaling, where local Ca 2+ …

Clozapine is usually considered as the last resort for treatment-resistant schizophrenia
(TRS). However, it shows limited efficacy in cognition improvement. Moreover, the metabolic …

The process of heme binding to a protein is prevalent in almost all forms of life to control
many important biological properties, such as O 2-binding, electron transfer, gas sensing or …

The prolonged usage of atypical antipsychotic drugs (AAPD) among individuals with
schizophrenia often leads to metabolic side effects such as dyslipidemia. These effects not …

Heme is an essential cofactor for multiple cellular processes in most organisms. In
developing erythroid cells, the demand for heme synthesis is high, but is significantly lower …

Objective. We conducted a meticulous bioinformatics analysis leveraging expression data of
226 PANRGs obtained from previous studies, as well as clinical data from AML patients …

UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play
important roles in the detoxification of endogenous and exogenous substrates. The 22 …