Background Cocaine addiction is a major public health problem. Despite decades of intense
research, no effective treatments are available. Both preclinical and clinical studies strongly …

The anterior cingulate cortex (ACC) is a ubiquitously active brain region, doubtless reflecting
a multiplicity of functions. Improved knowledge of such functions should progress …

Exposure to repeated, intermittent, escalating doses of amphetamine in rats disrupts
information processing in several tasks. Some of these deficits, notably impaired attentional …

Background Methamphetamine (meth) seeking progressively increases after withdrawal
(incubation of meth craving). We previously demonstrated an association between histone …

It has been proposed that some neuroadaptations that underlie behavioral sensitization may
play a role in the development and persistence of addiction. However, whether or not …

Drug addiction is a chronic disease defined by a complex set of characteristics, including
loss of control over drug intake and persistent drug craving, which primarily affects a small …

Rationale Subtypes of 50-kHz ultrasonic vocalizations (USVs) in rats are thought to reflect
positive affect and occur with cocaine or amphetamine delivery. In contexts predicting …

The development of drug addiction involves a transition from recreational use to compulsive
drug seeking and taking, and this progression can occur rapidly with cocaine use. These …

Among the different behavioral criteria used to discriminate substance dependence (or drug
addiction) from other non-disordered forms of drug use, drug intake escalation presents a …

Recent evidence suggests an important role for hypothalamic orexins/hypocretins in
modulation of drug reward and addiction-like behaviors in rodents. Our recent study has …