Drug addiction is a disorder in which drug seeking persists despite aversive consequences.
While it is well documented in animal models of drug sensitization that repeated drug …

Repeated cocaine administration induces many long-term structural and molecular changes
in the dorsal medial prefrontal cortex (dmPFC) and are known to underlie aspects of cocaine …

Investigators who study drug addiction are fortunate to have access to excellent animal
models. Such models will be invaluable in the assessment of factors involved in the …

Recent work has implicated the Lateral Habenula (LHb) in the production of anxiogenic and
aversive states. It is innervated by all the major monoamine neurotransmitter systems and …

Background This commentary discusses the important contributions of the article in this
issue by Matson and colleagues entitled “Selectively bred crossed high‐alcohol‐preferring …

Acute kappa opioid receptor (KOPr) activation by traditional agonists produces antiaddiction
properties, but side effects such as sedation and depression prevent their clinical use. The …

Laboratory animals allowed to self-administer stimulants for extended periods of time
escalate drug intake compared to animals that self-administer under temporally limited …

In terms of research into sport and crime, there has been considerable investigation into the
power of sport as a crime reduction tool. Evidence is far from conclusive and within the UK …

Background Rats with extended daily cocaine access show escalating cocaine self-
administration and behavioral signs of dependence. Regulation of glutamatergic …

This chapter addresses the use and effects of cocaine and psychostimulants. Stimulants
include a wide range of substances from cocaine to caffeine, or from amphetamine to …