TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

[HTML][HTML] Targeting PI3K/AKT signaling pathway in obesity

MS Savova, LV Mihaylova, D Tews, M Wabitsch… - Biomedicine & …, 2023 - Elsevier
Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Consumption of dietary anthocyanins and their association with a reduction in obesity biomarkers and the prevention of obesity

A Escalante-Aburto, MY Mendoza-Córdova… - Trends in Food Science …, 2023 - Elsevier
Background The emergency for treating obesity has increased, triggering severe economic
issues worldwide. The consumption of anthocyanins from different dietetic sources or by …

[PDF][PDF] The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases

JA Adetunji, KD Fasae, AI Awe, OK Paimo… - Heliyon, 2023 - cell.com
The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier
separating the blood and the tissues in several organs. ECs maintain endothelium integrity …

[HTML][HTML] A narrative review of approved and emerging anti-obesity medications

SA Beshir, AA Elnour, A Soorya, AP Mohamed… - Saudi Pharmaceutical …, 2023 - Elsevier
Background Recently, many drugs have been approved for halting overweight and obesity—
few types of research shifted to using Anti-obesity medications (AOM) solely for well-being …

Interaction of Jania rubens Polyphenolic Extract as an Antidiabetic Agent with α-Amylase, Lipase, and Trypsin: In Vitro Evaluations and In Silico Studies

A Nabil-Adam, ML Ashour, TM Tamer, MA Shreadah… - Catalysts, 2023 - mdpi.com
Jania rubens red seaweed has various bioactive compounds that can be used for several
medicinal and pharmaceutical applications. In this study, we investigate the antidiabetic, anti …

Study of anti-fatigue activity of polysaccharide from fruiting bodies of Armillaria gallica

H Sun, F Shu, Y Guan, F Kong, S Liu, Y Liu… - International journal of …, 2023 - Elsevier
Fatigue is a common physiological response that is closely related to energy metabolism.
Polysaccharides, as excellent dietary supplements, have been proven to have a variety of …

360-degree perspectives on obesity

M Cuciureanu, CC Caratașu, L Gabrielian… - Medicina, 2023 - mdpi.com
Alarming statistics show that the number of people affected by excessive weight has
surpassed 2 billion, representing approximately 30% of the world's population. The aim of …

An integrative framework to prioritize genes in more than 500 loci associated with body mass index

D Hemerich, V Svenstrup, VD Obrero, M Preuss… - The American Journal of …, 2024 - cell.com
Obesity is a major risk factor for a myriad of diseases, affecting> 600 million people
worldwide. Genome-wide association studies (GWASs) have identified hundreds of genetic …