Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is
maintained by specialized cells, such as macrophages. Macrophages express a variety of …

Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …

Research from over the past 20 years has implicated dipeptidyl peptidase (DPP) IV and its
family members in many processes and different pathologies of the immune system. Most …

The discovery of incretin-based medications represents a major therapeutic advance in the
pharmacological management of type 2 diabetes mellitus (T2DM), as these agents avoid …

Background NLRP3 inflammasome can be activated by high glucose and links inflammation
and metabolic disease. This study aimed to investigate the role of NLRP3 inflammasome in …

Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors are
commonly used treatments for patients with type 2 diabetes mellitus (T2DM). Both anti …

Macrophage foam cell formation, characterized by cholesterol ester accumulation catalyzed
by acyl-CoA: cholesterol acyltransferase 1 (ACAT1), is the hallmark of early atherogenesis …

Direct associations between hyperglycemia and atherosclerosis remain unclear. We
investigated the association between the amelioration of glycemia by sodium-glucose …

Background Anti-atherosclerotic effects of dipeptidyl peptidase-4 (DPP-4) inhibitors have
been shown in many studies. Since inflammation and immune response play a key role in …

Cardiovascular disease is one of the leading causes of mortality globally. Atherosclerosis is
an important step towards different types of cardiovascular disease. The role of oxidized low …