In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

Multiple sclerosis (MS) is a chronic, progressive disorder of the central nervous system
(CNS) that affects more than two million people worldwide. Several animal models resemble …

Dietary interventions have not been effective in the treatment of multiple sclerosis (MS).
Here, we show that periodic 3-day cycles of a fasting mimicking diet (FMD) are effective in …

Changes in gene expression that occur across the central nervous system (CNS) during
neurological diseases do not address the heterogeneity of cell types from one CNS region to …

Recent evidence suggests that astrocytes play an important role in regulating de-and
remyelination in multiple sclerosis. The role of astrocytes is controversial, and both …

Inflammation-mediated neurodegeneration occurs in the acute and the chronic phases of
multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis …

Microglia survey the brain microenvironment for signals of injury or infection and are
essential for the initiation and resolution of pathogen‐or tissue damage‐induced …

Discussions of multiple sclerosis (MS) pathophysiology tend to focus on T cells and B cells
of the adaptive immune response. The innate immune system is less commonly considered …

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous
clinical presentations and course. MS is considered to be a T cell mediated disease but in …

The central nervous system (CNS) is immune privileged with access to leukocytes being
limited. In several neurological diseases, however, infiltration of immune cells from the …