The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation,
transformation and death. Using mice and cells lacking AP-1 components, the target-genes …

Activator protein-1 (AP-1) was first identified as a transcriptional factor that binds to an
essential cis-ele-ment of the human metallothionein lla (hMTIla) promoter [1]. AP-1 is …

Lung and liver cancers are among the most deadly types of cancer. Despite improvements
in treatment over the past few decades, patient survival remains poor, underlining the need …

A plethora of physiological and pathological stimuli induce and activate a group of DNA
binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF …

This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

The purpose of this review is to discuss ATF3, a member of the ATF/CREB family of
transcription factors, and its roles in stress responses. In the introduction, we briefly describe …

Induction of phase 2 enzymes, which neutralize reactive electrophiles and act as indirect
antioxidants, is an important mechanism for protection against carcinogenesis. The …

Members of the Fos family (c-Fos, FosB and its smaller splice variants, Fra-1 and Fra-2)
dimerise with Jun proteins to form the AP-1 transcription factor complex. Based on the …

Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of
cellular processes including proliferation, apoptosis, differentiation, survival, cell migration …

The DNA binding activity of Fos and Jun is regulated in vitro by a post‐translational
mechanism involving reduction‐oxidation. Redox regulation occurs through a conserved …