Engineering extracellular vesicles as delivery systems in therapeutic applications

L Wang, D Wang, Z Ye, J Xu - Advanced Science, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into
the extracellular environment. Recent studies have shown that EVs serve as “messengers” …

How biomimetic nanofibers advance the realm of cutaneous wound management: The state-of-the-art and future prospects

N Eslahi, F Soleimani, R Lotfi, F Mohandes… - Progress in Materials …, 2024 - Elsevier
Skin acts as a protective barrier for the underlying organs against external events such as
irradiation of ultraviolet rays, incursion of harmful pathogens, and water evaporation. As the …

Microfluidic systems for particle capture and release: A review

L Gong, A Cretella, Y Lin - Biosensors and Bioelectronics, 2023 - Elsevier
Microfluidic technology has emerged as a promising tool in various applications, including
biosensing, disease diagnosis, and environmental monitoring. One of the notable features of …

[HTML][HTML] Frontier review of the molecular mechanisms and current approaches of stem cell-derived exosomes

LY Chen, TW Kao, CC Chen, N Niaz, HL Lee, YH Chen… - Cells, 2023 - mdpi.com
Exosomes are effective therapeutic vehicles that may transport their substances across cells.
They are shown to possess the capacity to affect cell proliferation, migration, anti-apoptosis …

[HTML][HTML] Exosomes in cardiovascular disease: from mechanism to therapeutic target

AB Reiss, S Ahmed, M Johnson, U Saeedullah… - Metabolites, 2023 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In
recent decades, clinical research has made significant advances, resulting in improved …

[HTML][HTML] Engineered exosomes and composite biomaterials for tissue regeneration

W Hu, W Wang, Z Chen, Y Chen, Z Wang - Theranostics, 2024 - ncbi.nlm.nih.gov
Exosomes, which are small vesicles enclosed by a lipid bilayer and released by many cell
types, are widely dispersed and have garnered increased attention in the field of …

[HTML][HTML] A pipeline for the development and analysis of extracellular vesicle-based transcriptomic biomarkers in molecular diagnostics

C Grätz, M Schuster, F Brandes, AS Meidert… - Molecular Aspects of …, 2024 - Elsevier
Extracellular vesicles are shed by every cell type and can be found in any biofluid. They
contain different molecules that can be utilized as biomarkers, including several RNA …

Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders

K Yadav, R Vijayalakshmi, KK Sahu, P Sure… - European Journal of …, 2024 - Elsevier
Delivering drugs to the brain is a complex challenge in medical research, particularly for
disorders like Alzheimer's and Parkinson's. The blood–brain barrier restricts the entry of …

Recent trends in the use of small extracellular vesicles as optimal drug delivery vehicles in oncology

SK Kumar, MV Sasidhar - Molecular Pharmaceutics, 2023 - ACS Publications
Small extracellular vesicles (sEVs) are produced by most cells and play an important role in
cell-to-cell communication and maintaining cellular homeostasis. Their ability to transfer …

Insight into the Functional Dynamics and Challenges of Exosomes in Pharmaceutical Innovation and Precision Medicine

A Sharma, A Yadav, A Nandy, S Ghatak - Pharmaceutics, 2024 - mdpi.com
Of all the numerous nanosized extracellular vesicles released by a cell, the endosomal-
originated exosomes are increasingly recognized as potential therapeutics, owing to their …