Adenosine receptors modulate neuronal and synaptic function in a range of ways that may
make them relevant to the occurrence, development and treatment of brain ischemic …

Summary Background Ticagrelor, a P2Y 12 antagonist, is an antiplatelet agent approved for
the treatment of acute coronary syndromes; it also inhibits adenosine uptake by erythrocytes …

Conventional reinforcers phasically stimulate dopamine transmission in the nucleus
accumbens shell. This property undergoes one‐trial habituation consistent with a role of …

Adenosine, an ubiquitous neuromodulator, and its analogues have been shown to produce
'depressant'effects in animal models believed to be relevant to depressive disorders, while …

The adenosine A2a receptor belongs to the seven transmembrane helix G‐protein‐coupled
receptor family, is abundant in striatum, vasculature and platelets and is involved in several …

Adenosine and adenosine receptors (ARs) are increasingly recognized as important
therapeutic targets for controlling cognition under normal and disease conditions for its dual …

The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …

There is now good reason to believe that blockade of the adenosine A 2A receptor could be
of value in the treatment of Parkinson's disease. Peter J. Richardson, Hiroshi Kase and Peter …

Background: Chronic treatment with l-3, 4-dihydroxyphenylalanine (l-dopa) is often
associated with motor side effects in PD patients. The search for new therapeutic …

Endogenous adenosine in nervous tissue, a central link between energy metabolism and
neuronal activity, varies according to behavioral state and (patho) physiological conditions; it …