Background—We determined whether repeated caffeine administration at different dosages
and for different periods of time (400 or 600 mg/d for 1 week or 400 mg/d for 2 weeks) …

Amotivational states and insufficient recruitment of mental effort have been observed in a
variety of clinical populations, including depression, traumatic brain injury, post-traumatic …

Alveolar macrophage (AM) responses are commonly induced in inhalation toxicology
studies, typically being observed as an increase in number or a vacuolated …

Modulation of neuronal circuits is key to information processing in the brain. The majority of
neuromodulators exert their effects by activating G-protein-coupled receptors (GPCRs) that …

The present study has demonstrated that the sleep‐promoting potency of 2‐[p‐(2‐
carboxyethyl) phenethylamino]‐5′‐N‐ethylcarboxamido adenosine (CGS21680), a …

To date, numerable reviews are found in the literature prominent to the effect of caffeine on
the immune system, with the latest review published in 2006. Database screening reveals …

Human adenosine A2A and rat dopamine D2 receptors (A2A and D2 receptors) were co-
transfected in Chinese hamster ovary (CHO) cells to study the interactions between two …

Besides its well-known psychoactive effects, caffeine has a broad range of actions. It
regulates several physiological mechanisms as well as modulates both native and adaptive …

In order to investigate the role of adenosine A2A receptor blockade on dopamine-mediated
motor responses, contralateral turning behaviour and expression of the early-gene c-fos was …

Design, Radiosynthesis, and Biodistribution of a New Potent and Selective Ligand for in Vivo
Imaging of the Adenosine A2A Receptor System Using Positron Emission Tomography …